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Antibacterial fabrics modified with betulin for medical and general applications

Sowiński Artur D., Tarachowicz Ludwik A., Kłeczek Anna, Brzezińska Natalia, Pyza Maciej, Gabor Jadwiga, Gierek Zuzanna, Zabrowarny Adam, Swinarew Andrzej S.

Engineering of Biomaterials

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2023

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vol. 26, no. 169

23--26

EN

This study examines the potential use of betulin as an alternative to silver in enhancing vinyl-coated fabrics. Silver, commonly used to impart antimicrobial properties to polymers, raises environmental and cytotoxicity concerns. Betulin, known for its antibacterial, anti-inflammatory, antiviral, and antifungal characteristics, emerges as an eco-friendly alternative. The study highlights the possible applications of betulin in various sectors, such as medical, military, and public settings, where addressing the challenge of harmful biofilms is critical. The aim of this research was to assess the possible effectiveness of betulin as a modifier in polyvinyl chloride (PVC) coated textiles. The study involved extracting betulin, preparing plasticizer-based betulin premix, incorporating it into plastisol, and then coating fabrics to analyze its effect on surface bioactivity. Preliminary tribological studies were conducted to assess the durability of the coating. According to the ISO 22196:2007 standard, significant antibacterial effects were observed, with an activity rating (R) ranging between 1.55 and 2.0. In addition, tribological studies indicated an improvement in coating durability compared to conventional PVC coatings. The results suggest that betulin shows potential as a cost-efficient and environmentally friendly alternative, contributing to improved product functionality while minimizing environmental impact. Further research is planned to investigate the potential of betulin in polymer modification and to exploit its positive impact on human health and environmental sustainability.

2

Polylactide-based composite materials for 3D printing and medical applications - the effect of basalt and silicon dioxide addition

Pyza Maciej, Brzezińska Natalia, Kulińska Karolina, Gabor Jadwiga, Barylski Adrian, Aniołek Krzysztof, Garczyk-Mundała Żaneta, Adebesin Kayode, Swinarew Andrzej

Engineering of Biomaterials

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2022

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vol. 25, no. 166

29--39

EN

Polymers are compounds that play a key role in the development of many fields of science, including emergency medicine. Currently, there are increasing requirements for biomedical polymers in terms of producing lighter and more ecological equipment. To meet these requirements, a composite material was developed: polylactide (PLA) with the addition of modifiers - basalt and silicon dioxide (SiO2). PLA was chosen as a biodegradable polymer that naturally decomposes in the environment. This is very important, regarding a large number of single-use materials made of microplastics polluting the environment. The samples were made by additive 3D printing and then immersed in swimming pool water, chlorine solution, and distilled water. FTIR analysis showed the influence of the environment on the intensity and shift of PLA absorption bands. Microscopic analysis provided information on surface morphology, roughness, and potential defects. Tribological and micromechanical tests showed that the additions of basalt and silica to the PLA material influenced the morphological structure and the average area of the wear trace, volumetric wear, and average coefficient of friction. In the presence of chlorine solution, distilled water, and pool water under real conditions, the SiO2 addition made the PLA material more resistant to abrasion, as compared to the basalt addition. However, additives did not significantly affect the PLA material hardness, and the samples with basalt turned out to be more resistant to deformation.

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Fabrication of filter membrane of organic compound to protect the upper respiratory tract from viral and bacterial infections, including SARS-CoV-2, compliant with FFP2 standard

Brzezińska Natalia, Pyza Maciej, Kłeczek Anna, Kulińska Karolina, Gabor Jadwiga, Garczyk-Mundała Żaneta, Świnarew Andrzej

Engineering of Biomaterials

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2022

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vol. 25, no. 166

2--11

EN

Bacteria, viruses, and other pathogens in the surrounding environment are biological threat to human health and life. The development of various diseases in the world, as well as the pandemic caused by the rapid spread of the SARS-CoV-2 virus, have increased the demand for the use of upper respiratory protection devices. Out of concern for the natural environment, the aim of this work was to develop an innovative solution i.e. the FFP3 filtering membrane made of an organic compound. First, preliminary tests of the FFP2 mask were carried out to assess the chemical composition, morphological structure - fibers geometry, thickness, density, and arrangement. The FTIR analysis study was conducted to confirm that the main chemical in the mask was polypropylene (PP) and high-density polyethylene (HDPE). Optical, confocal microscopy and computer microtomography studies showed the fibers structure. They were densely arranged and their thickness was less than 1 den. The fiber structure of the FFP2 mask was also compared before and after immersing in betulin, an organic compound obtained from birch bark via the Soxhlet extraction. In addition, the assessment of microbiological activity was made on the reference strain Escherichia coli ATCC 25922, and the anti-inflammatory activity on normal human skin fibroblasts on polycarbonate with betulin. The studies showed that betulin supported the material antibacterial and anti-inflammatory properties.

4

Modern porous polymer and carbon materials based on polyurethanes for applications in medical diagnostics

Swinarew Andrzej S., Kubik Klaudia, Gabor Jadwiga, Paluch Jarosław, Popczyk Magdalena, Stanula Arkadiusz, Okła Hubert, Świerczyński Adam

Engineering of Biomaterials

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2021

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Vol. 24, no. 163

33

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Symulacja oraz badania wytrzymałości struktur przestrzennych modeli otrzymanych metodą druku 3D-FDM

Swinarew Andrzej S., Gabor Jadwiga, Kubik Klaudia, Popczyk Magdalena, Swinarew Beata, Okła Hubert, Żarnowski Mirosław, Stanula Arkadiusz

Przemysł Chemiczny

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2020

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T. 99, nr 3

373--377

PL

Dokonano oceny metody doboru najkorzystniejszej struktury wewnętrznej dla elementów pracujących w warunkach przenoszenia naprężeń. Przedstawiono czynności związane z zaprojektowaniem modeli do druku 3D, a także opisano ich zachowanie podczas badań wytrzymałościowych.

EN

Six geometric models with different internal structures were designed by using a computer-aided procedure (shape program) and 3-dimensionally printed by incremental technol. A polyol-modified and SiO2 nanoparticles-filled polycarbonate was used as the filament. The model with the large hexagon structure showed the highest compressive strength and with the circular structure showed the lowest one. A large discrepancy between the simulated and actual values of compressive strength was obsd.

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Organic bacteriostatic material

Flak Tomasz, Paluch Jarosław, Gabor Jadwiga, Okła Hubert, Stanula Arkadiusz, Markowski Jarosław, Plich Jan, Swinarew Andrzej S.

Engineering of Biomaterials

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2020

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Vol. 23, no. 155

17--21

EN

The use of antibiotics to treat bacterial infections is becoming less and less effective year by year due to the increasing resistance of bacteria. The microbial evolutionarily acquired resistance to antibiotics increases the threat to man’s life due to difficulties regarding effective therapies to fight infections. Therefore, apart from treatment, it is necessary to introduce appropriate prophylaxis which limits the multiplication of bacterial colonies on everyday use objects. Due to the antibiotic resistance phenomenon, it is important to find a new material with antibacterial properties for FDM 3D printing in medical applications. The work contains research on a new chemical compound used as an additive to thermoplastics. The rhodamine derivative was synthesized via the 4-diphenylaminobenzaldehyde reaction with 1.3-indendione in a boiling mixture of EtOH/H2SO4. The obtained chemical compound was used as a bacteriostatic modifier of the polycarbonate (PC) properties, as such a modification enables application e.g. for medical device housings or for surfaces frequently touched by people. The modifier and the commercially available polymer were compounded with a high-temperature screw extruder and a filament for FDM 3D printer was created. The modified polymer revealed antibacterial properties relative to Escherichia coli and good thermal stability during the processing.

7

Porowate materiały poliuretanowe do zastosowań w diagnostyce medycznej

Swinarew Andrzej S., Muskus Maciej, Gabor Jadwiga, Paluch Jarosław, Popczyk Magdalena, Swinarew Beata, Stanula Arkadiusz, Kubik Klaudia K., Okła Hubert, Liszka Barbara

Przemysł Chemiczny

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2019

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T. 98, nr 2

251--256

PL

Opracowano proces wytwarzania pianek węglowych (synteza, karbonizacja), a także dokonano ich szerokiej charakterystyki, wykorzystując mikroskopię świetlną, skaningową mikroskopię elektronową SEM, mikrotomografię komputerową μCT, spektroskopię w podczerwieni FT-IR i chromatografię gazową sprzężoną z detektorem mas GC-MS. Wyniki przeprowadzonych badań umożliwiły wyselekcjonowanie pianek o najlepszych właściwościach sorpcyjnych, które mogą znaleźć zastosowanie w diagnostycznych badaniach fazy oddechowej.

EN

Polyurethane (PUR) foams were synthetized from polyols and methylene diphenyl diisocyanate polymers at mass ratios 1:1, 1:3 and 3:1 without any catalyst or in its presence. The porous structure of the PUR foams was detd. by using scanning electron microscopy and high-resolution 3D computed tomog. The PUR foams showed a good sorbability and could be used in the human diagnostic (respiratory phase).