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1 2005

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Frequency analysis of ictal EEG neocortical epileptic discharges in cats: comparison between potassium and penicillin induced seizures

Sobieszek A., Tarnecki R., Zalewska E.

Biocybernetics and Biomedical Engineering

2005

Vol. 25, no. 1

37-47

Results of this research illustrate similarities as well as differences between patterns of the cortical EEG ictal discharges and their frequency spectra recorded in two experimental, animal models of epilepsy in cats. Localized bioelectric discharges were evoked in animals with permanently implanted electrodes either by local, subdural. epicortical application of penicillin or subdural perfusion of the parietal cortex with artificial cerebrospinal fluid (aCSF) with elevated concentration of potassium ions up to 16 mM/dcm3. Three classes of components were distinguished: low frequency surface negative spikes and surface positive waves with subsequent negativity, appearing at theta-delta frequencies (2-4 Hz), recorded in both experimental conditions and high frequency component in beta frequency range (13-35 Hz) recorded after administration of penicillin. A typical pattern of spike and slow wave complexes was characteristic for ictal discharges evoked by high potassium aCSF. High frequency "beta" component was observed after topical administration of penicillin and was preserved after administration of substances belonging to the two classes of potent antiepileptic drugs: barbiturates and benzodiazepines. The results provide experimental evidence linking disturbances of the neuronal potassium ion homeostasis in the cerebral cortex with the appearance of EEG spike and slow wave pattern characteristic for absence epilepsy.