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2 International Letters of Chemistry, Physics and Astronomy

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Microwave Induced Facile One-Pot Access to Diverse 2-cyanobenzothiazole-A Key Intermediate for the Synthesis of Firefly Luciferin

Prajapati N. P., Vekariya R. H., Patel H. D.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 44

81--89

An eco-friendly one-step preparation of various substituted 2-cyanobenzothiazole by condensation of corresponding substituted ortho-aminothiophenol with ethyl cyanoformate, employing an effective amount of Lawesson’s reagent, under microwave irradiation (MWI) and solvent free conditions is presented. The structures of the compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and mass spectral data. The targeted various substituted 2-cyanobenzothiazole are obtained in good yields and high purity.

Synthesis and in vitro antibacterial and antifungal evaluation of quinoline analogue azetidin and thiazolidin derivatives

Prajapati S. M, Vekariya R. H., Patel K. D., Panchal S. N., Patel H. D., Rajani D. P., Rajani S.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 20, iss. 2

195--210

A library of quinoline analog two novel series of azetidin (SH1-5) and thiazolidin (SHa-e) derivatives were designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and mass spectral data. These novel synthesized compounds were evaluated for antibacterial activity against two gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus) and two gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also studied for their antifungal activity with Candida albicans, Aspergillus niger, Aspergillus clavatus using the broth dilution technique. Most of the compounds were the best bio-active desired antibacterial analog with less MIC value against different tested strains.