Wyniki wyszukiwania - BazTech

1

Synthesis and Structure of (4S,5S)-(–)-p-Methylthio Analogue of (4S,5S)-(+)-Isocytoxazone

Grajewska A., Rozwadowska M.D., Gzella A.

Polish Journal of Chemistry

|

2007

|

Vol. 81, nr 11

1861-1868

EN

(+)-Thiomicamine, an industrial waste product, has been transformed into (–)-(4S,5S)- 4-hydroxymethyl-5-p-methylthiophenylxazolidin-2-one, a sulfur analog of isocytoxazone, the regioisomer of the potent cytokine modulator, (–)-cytoxazone.

2

Enantioselective Oxidation of Metghyl p-Totyl Sulfide Catalyz4ed by Chiral Schiff Base-Vanadium Complexes

Głuszyńska A., Krajewska K., Rozwadowska M. D.

Polish Journal of Chemistry

|

2003

|

Vol. 77 / nr 11

1703-1710

EN

Oxidation of methyl p-tolyl sulfide with hydrogen peroxide catalyzed by VO(acac)2 - Schiff base 12 complex afforded R-(+)-methyl p-tolyl sulfoxide in high yield and with 43% e.e. Recrystallization of the product from ethyl ether/hexane resulted in the sulfoxide enantiomerically enriched up to 99.7% [m.p. 71-74_C; [_]D +144.6_ (c = 2.02, acetone)].

3

Synthesis of Isoquinoline Alkaloid, (š)-Salsolidine, Using Thiazolino[2,3-a]isoquinolinone S-Oxide as Intermediate

Rozwadowska M. D., Sulima A.

Polish Journal of Chemistry

|

2001

|

Vol. 75, nr 12

1847-1852

EN

Thiazolino[2,3-a]isoquinolinones have been oxidized to the corresponding S-oxides and their 10b-methyl derivatives desulfurized with Raney nickel to give (š) N-acyl salsolidine. Base-catalyzed hydrolysis of the N-acetyl derivative afforded (š)-salsolidine. C-Methylation reactions of the title heterocyclic system have been investigated throughly. Stereochemistry ofthe synthesized compounds nas been established.

4

Total synthesis of (+)- and (-)-corydalisol

Chrzanowska M., Józkowiak J., Rozwadowska M.D., Sulima A.

Polish Journal of Chemistry

|

1998

|

Vol. 72, nr 11

2399-2404

EN

The first total synthesis of enantiomerically enriched (+)- and (-)-corydalisol (1) has been performed by addition of lithiated optically pure 1,3-dithiane 3b to hydrastinine chloride (2a), followed by desulfurization, separation of diastereomers and reduction with lithium aluminum hydride.

5

Crystal structure of nitromethane solvated (-)-2(3,4-dimethoxyphenyl)-4-phenyl-5-phthalimido-1,3-dithiane

Ratajczak-Sitarz M., Rozwadowska M.D., Katrusiak A.

Polish Journal of Chemistry

|

1998

|

Vol. 72, nr 11

2493-2499

EN

The crystal structure of the title solvate has been determined by X-ray diffraction with R=0.065. The 1,3-dithiane ring presents a chair conformation, the substituents at C(2), C(4) and C(5) are all in equatorial positions and the molecular ratio of the solvate is 1:1.