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Design and manufacture of krypton gas target for 81Rb production at a 30 MeV cyclotron

Rovais M.R.A., Mirzaii M., Kiyomarsi M., Yousefi K., Shadanpour N., Ensaf M. R.

Nukleonika

2010

Vol. 55, No. 2

225-231

The cyclotron of nuclear medicine research group at the Agricultural, Medical and Industrial Research School (AMIRS) has been producing several radionuclides such as 201Tl, 67Ga, 18F and 81Rb for nuclear medicine centers. Gas targets are utilized in a variety of cyclotron producing radionuclides which are used in nuclear medicine centers. We report a method for the design and manufacture of a cyclotron gas target which facilitates both the collection and processing of the krypton gas target as well as the desired 81Rb. In this study a gas target was designed for routine production of 81Rb (for a 81Rb/81mKr generator) through the nuclear reaction natKr(p,2n)81Rb → 81mKr. The incident energy of protons on the target was 26.5 MeV. The gas target was made of stainless steel. The length of the target was 251 mm with double titanium windows, 20 μm in thickness. A production yield of 3.18±0.27 mCi/μA·h was obtained which was more than 80% of the calculated yield (4.1 mCi/μA·h).

Production, quality control and initial imaging studies of [82mRb]RbCl for PET studies

Rowshanfarzad P., Jalilian A., Kiyomarsi M., Sabet M., Karimian A., Moradkhani S., Mirzaii M.

Nukleonika

2006

Vol. 51, nr 4

209-215

Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/mAh was obtained.