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Functional brain imaging by multi-wavelength time-resolved near infrared spectroscopy

Torricelli A., Contini D., Pifferi A., Spinelli L., Cubeddu R.

Opto-Electronics Review

2008

Vol. 16, No. 2

131-135

We present a description of evolution of time-resolved systems developed at the Department of Physics, Politecnico di Milano for tissue oximetry and functional brain imaging. From a single source and 4-channel set-up we have upgraded to a potentially 18-sources and 64-channel device. An example of sensitivity of the latest set-up is reported for a motor task experiment. A short discussion on the next generation time-resolved instrumentation for functional studies is also presented.

Time-resolved optical spectroscopy and imaging of breast

Taroni P., Pifferi A., Torricelli A., Cubeddu R.

Opto-Electronics Review

2004

Vol. 12, No. 2

249-253

A fully automated system for time-resolved reflectance and transmittance spectroscopy from 610 to 1010 nm was developed and applied to the optical (absorption and scattering) characterization of breast tissue in vivo. From absorption spectra, information is derived on tissue content of oxy-, deoxyhemoglobin, water and lipids, while scattering spectra provide knowledge on tissue structure. A portable system for breast imaging at four wavelengths (683, 785, 912, and 975 nm) was also developed and is being tested in clinics for the detection and characterization of breast lesions (optical mammography).