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1

A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products

Antić D., Filipić S., Agbaba D.

Acta Chromatographica

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2007

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No. 18

199-206

EN

A simple, conventional TLC method has been established for separation of clopidogrel and its hydrolytic product SR 26334, the main impurity in clopidogrel. Use of aluminium foil-backed silica gel 60F254 plates with n-heptane–tetrahydrofuran, 1:1 (v/v), as mobile phase, enabled successful separation of clopidogrel in high excess from the impurity. The separated compounds were detected at 230 nm. Regression coefficients (r ≥ 0.999), recovery (94.5–107.1%), and limit of quantification (0.047 mg mL-1) were evaluated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of clopidogrel both in raw material and in dosage forms.

2

Analyzing, Modeling and Simulation of the Cascade Connected Transporters in Tyre Industry Using Signal and Bond Graphs

Trajkocić D., Nikolić V., Antić D., Danković B.

Machine Dynamics Problems

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2005

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Vol. 29, No. 3

91--106

EN

In the paper the bond graphs modeling and simulation a cascade system for protector cooling in tyre industry using Bondsim Simulink library have been presented. The example of cascade system that the use of Bondsim library will simplify the modeling and simulation has been shown. Using signal graph for obtaining the state space model is presented.

3

Obtaining State Space Model from Bond Graph Model with Derivative Causality Using Laplace Transform

Antić D., Stanković L., Nikolić V.

Machine Dynamics Problems

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2003

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Vol. 27, No. 2

5-10

EN

One method for obtaining the state space model from the bond graph model is based on using signal graph as an indirect tool. In case the signal graph nodes are time functions, the direct state space model obtaining is only possible for bond graphs with integral causality. Interposing the Laplace operator "s" into the signal graph is proposed in this paper. Thus, in case of derivative causality presence in the bond graph as well, the necessary transformations of the equations are minimized.

4

Application of Signal Flow Graph Theory for Obtaining State Space Model from Bond Graph Model with Derivative Causality

Antić D., Stanković L., Danković B., Nikolić V.

Machine Dynamics Problems

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2003

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Vol. 27, No. 1

5--13

EN

In this paper, a new approach for deriving state space equations from a causal bond graph, in which there is derivative causality as well, on the basis of the equivalent signal flow graph is presented. By following ”the paths of traveling” of two general bond graph variables (the effort e and the flow f) through the causal bond graph, the equivalent signal flow graph is obtained. On the basis of that signal flow graph, a system of equations, in which the first derivatives of the state variables are implicitly expressed, by which the arranging of the state space model is obtained, is formed.

5

Sliding Mode Control with Fuzzy Tuning for Position Tracking of an Electro-Hydraulic Actuator

Antić D., Nikolić V., Mihajlov M., Aleksić K.

Machine Dynamics Problems

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2002

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Vol. 26, No. 1

81-93

EN

This paper considers the position control problem of an electro-hydraulic actuator subjected to parameter uncertainties and an external disturbance. The system is described by a comprehensive model that accounts for nonlinearities and friction effects. Friction in the hydraulic cylinder and load variations are taken into account as the external disturbance. The variable structure control with a sliding mode is used in the first step of the controller design. In order to overcome known drawbacks of the sliding mode control, fuzzy logic is applied. The simulation results show good tracking performance and strong robustness.