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NMR-based metabonomics of cerebrospinal fluid applied to amyotrophic lateral sclerosis

Toczyłowska B., Jamrozik Z., Liebert A., Kwieciński H.

Biocybernetics and Biomedical Engineering

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2013

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Vol. 33, no. 1

21--32

EN

The aim of this study was applications of cerebrospinal fluid (CSF) NMR-based metabolic fingerprinting to amyotrophic lateral sclerosis (ALS) as possible early diagnostic tool. Two CSF sample categories were collected: 9 ALS patients and 13 age-matched control patients (without neurological disease). Metabolic profile of the CSF was determined by high resolution proton NMR spectroscopy. For statistical analysis magnitudes of 33 signals of the NMR spectrum were selected. Partial least square discriminant analysis (PLS-DA) and orthogonal PLS-DA (OPLS-DA) modeling were used to find potential biomarkers of the disease. Those analyses showed that it was possible to distinguish the ALS patients from the control ones on the basis of the CSF metabolic profile. Significantly higher levels of metabolites observed in the patients with ALS may represent the state of anaerobic metabolism and excitotoxicity.

2

Analysis of matrix metalloproteinases (MMPs) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS)

Sokołowska B., Jóźwik A., Niebroj-Dobosz I., Janik P., Kwieciński H.

Journal of Medical Informatics & Technologies

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2009

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Vol. 13

147--150

EN

Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of motor neuron degeneration in amyotrophic lateral sclerosis (ALS) and might be potential markers of diagnosis, prognosis and monitoring treatment effects. The aim of the present study was evaluation of the MMPs significance in cerebrospinal fluid (CSF MMPs) of patients with ALS in relation to severity of the disease. Metalloproteinases MT-MMP-1, MMP-2, MMP-9 and additionally age of subjects and disease duration were analyzed. The results demonstrate that the error of differentiation between healthy subjects and ALS patients (for MMP-2 feature) as well as between mild and severe ALS states (for CSF MMPs set) equalled to 0.033. In conclusion, the pattern recognition approach may be useful for differentation of ALS progressing on the basis of CSF MMPs features.

3

Pattern recognition approach to differentiation of disease severity in patients with amyotrophic lateral sclerosis

Jóźwik A., Sokołowska B., Niebroj-Dobosz I., Janik P., Kwieciński H.

Journal of Medical Informatics & Technologies

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2008

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Vol. 12

143--147

EN

A possibility of recognition of the clinical status of patients with amyotrophic lateral sclerosis (ALS) in relation to severity of the disease was investigated. Three groups: (i) healthy controls (n=15) and two subgroups of ALS patients (ii) mild (n=15) and (iii) severe (n=15) were considered as classes. Four features of the subjects: (i) their age (AGE) (ii) erythropoietin concentration in serum (SERUM), (iii) in cerebrospinal fluid (CSF), and (iv) duration time of the disease (Tdis) were used for classifier construction based on the k Nearest Neighbours (k-NN) rule, known from pattern recognition theory. The presented results demonstrate that the pattern recognition approach may be useful for the evaluation of the severity of the ALS disease.

4

Regulacja środkowego odcinka cieku Zielonka w Parku Leśnym Arkońskim w Szczecinie

Wira J., Kwieciński H.

Zeszyty Naukowe. Inżynieria Środowiska / Politechnika Zielonogórska

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2001

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nr 125

373-380

PL

W referacie przedstawiono problem zagrożenia i ochrony lokalnego środowiska przyrodniczego Parku. Przedstawione zagrożenia mają charakter zarówno naturogeniczny jak i antropogeniczny. Zaistniałe, nieodwracalne zmiany w środowisku doliny miejscowego strumienia spowodowane zostały nawałnicą w czerwcu, a następnie gwałtowną ulewą w lipcu 1997 roku a ich rozmiar został spotęgowany tzw. "uszczelnieniem" przez zabudowę mieszkaniową wyżej położonych partii terenów zlewni. Zastosowanie lokalnego, suchego zbiornika retencyjnego z zespołem spustowo-przelewowym sytuowanego na obrzeżu Parku umożliwia bardzo wysokie zdławienie przepływów ekstremalnych poniżej ww. budowli a w konsekwencji zdecydowane obniżenie kosztów regulacji strumienia leśnego przepływającego przez niżej położone głębokie wąwozy leśne.

EN

This text described problems conected with environmental protection of local nature of Park Leśny Arkoński. Presented problems are naturogenic and anthropogenic. That was cased by storms in june and july 97. Big rains and very closed standing buildings were reasons of reinforcing this phenomenon. Local dry tank builded closed to Las Arkoński Park will be possibility for lowering costs of exploitation forest warters streaming is Las Arkoński Park.