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DomAns - pattern based method for protein domain boundaries prediction and analysis

Antczak M., Blazewicz J., Lukasiak P., Milostan M., Krasnogor N., Palik G.

Foundations of Computing and Decision Sciences

2011

Vol. 36, No. 1

35-56

Determination of the native folded structure for a particular protein is a milestone towards understanding its function, and in most cases, can be done experimentally. However, the ability to predict in silico protein structure and related features would represent a fundamental breakthough in structural biology. The ability to predict domains in proteins is amongst the most important tasks needed for efective functional classification, homology-based structure prediction, structural genomics, as it makes function prediction easier. In this paper, we present the DomAnS, protein domain prediction approach, that is based on pattern alignment. DomAnS allows rapid screening for potential domain regions with the ability to recognize the most promising regions where domains might exists. The combination of the DomAnS algorithm with specialized databases that contains all known domains, allows us to find domain regions without solving 3D structure. Our approach has been tested on CASP7 data, and for 28 targets gave the best overall score.

Sequence similarity based method for protein function prediction

Blazewicz J., Lukasiak P., Milostan M., Krasnogor N., Jackowiak P.

Foundations of Computing and Decision Sciences

2009

Vol. 34, No. 3

173-191

Motivation: Proteins are the main building blocks of life. They catalyze biological processes in living cells to sustain life and improve metabolism. They also act as biological scaffolds and are cell's workhorses. As a matter of fact, knowing their function is one of the most important milestones for understanding life.The function depends on the tertiary structure of the protein, but only for a fraction of amino acid sequences gathered in databases the structure is known. Thus, creation of efficient and accurate methods that predict function from sequences, based on already known function-sequence assignments, is a fundamental challenge in computational biology. Results: First, we show a detailed analysis of a usability of similarity search engines in the context of function prediction. Then we propose a simple and effective method for assigning function to sequences based on the results of similarity searches and information gathered from gene ontology annotation graphs. Availability: All data used for the analysis presented in this paper as well as raw result are available at the site: http://bio.cs.put.poznan.pl/funcpred/data/ Suplementary Material: Suplementary materials with additional charts are available at: http://bio.es.put.poznan.pl/funcpred/suplement/ Contact: protbio@cs.put.poznan.pl