This research was conducted to assess various bioactive compounds in the meat of mudskippers found in the Sungsang 2 Village, Banyuasin regency, South Sumatra. The research had been synthesized using n-hexane from February to May 2018 at Agricultural Technology Production Laboratory, Sriwijaya University. Subsequently, the mudskippers (Periopthalmus chrysospilos, Boleopthalmus boddarti, and Periophthalmodon schlosseri) extract was synthesized and further investigate by conducting the GC-MS analysis. The study of bioactive compounds in mudskippers was carried out by evaporating in vacuum evaporation at 30°C. The results showed that Periopthalmus chrysospilos has five classes of bioactive compounds such as steroids, terpenoids, carotenoids, canabinoids, and alkaloids and Boleopthalmus boddarti has five classes of bioactive compounds including steroids, carotenoids, terpenoids, bufadienolides, and carotatoxins. Furthermore, Boleopthalmus dussumieri has four classes of bioactive compounds such as steroids, carotenoids, terpenoids, and carotatoxins and Periophthalmodon schlosseri has three classes of bioactive compounds including steroids, carotenoids and terpenoids. This research discussed the potential benefit of all bioactive compounds in mudskippers for alleviating and treating children with enuresis through the review of literature on the most cited bioactive compounds.
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