Wyniki wyszukiwania - BazTech

Ograniczanie wyników

2 Polish Journal of Chemistry

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Syntheses of N,S-Substituted 4-Chloro-2-mercapto-5-methylbenzenesulfonamide Derivatives with Potential Biological Activity

Pomarnacka E., Kornicka A., Bednarski P. J., Charkiewicz A.

Polish Journal of Chemistry

2009

Vol. 83, nr 1

65-73

The syntheses of N,S-substituted 4-chloro-2-mercapto-5-methylbenzenesulfonamide derivatives are described. The compounds 6-11, 14, 15 and 19-22 were tested for their in vitro anticancer activity against 9 human cancer cell lines. The most active compounds 6, 9 and 20 showed moderate cytotoxic activity and were approximately 5-fold less potent than cisplatin.

Synthesis and Anti-HIV Activity of 4-Chloro-2-mercapto-N-(1,4,5,6-tetrahydro-1,2,4-triazin-3-yl)benzenesulfonamide Derivatives

Pomarnacka E.

Polish Journal of Chemistry

2007

Vol. 81, nr 3

345-352

The synthesis of 4-chloro-2-mercapto-N-(1,5-dimethyl- or 1-alkyl-1,4,5,6-tetrahydro- 1,2,4-triazin-3-yl)benzenesulfonamides 15-28 is described. Suggested mechanism of the investigated reaction is discussed. The compounds 15-17 and 19 were tested for their in vitro anti-HIV potency at the National Cancer Institute and only 4-chloro-2- mercapto-N-(1-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl)benzenesulfonamide (15) showed reasonable activity (TI50 = 6.21).