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1
Content available remote Synthesis, Spectral Studies Antibacterial and Antifungal Activity of 2" – Amino - 4" - [2 - (4' -chlorophenyl)-6-methyl imidazo[1, 2-a] pyridin-3-yl]-6"-aryl Nicotinonitrile
Bhuva V. V., Bhadani V. N., Purohit H. D., Purohit D. M.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 49
161--166
EN
Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – amino - 4" - [2 - (4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitriles ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.
2
Content available remote Synthesis, Spectral Studies, Antibacterial and Antifungal Activity of 2" – Methoxy - 4" -[2 - (4' -chlorophenyl)-6-Methyl Imidazo [1, 2-a] Pyridin-3-yl]-6"-Aryl Nicotinonitrile
Bhuva V. V., Bhadani V. N., Purohit H. D., Purohit D. M.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 49
155--160
EN
Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – methoxy - 4" - [2 - ( 4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitrile( 4a-4l ) has been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50µg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.
3
Content available remote Synthesis, Spectral Studies and Biological Screening of 2-(4'-chlorophenyl)-6-methyl-(3-N, n’-Diaryl/Dialkyl Amino methyl)-imidazo[1,2-a]pyridine
Bhuva V. V., Bhadani V. N., Purohit H. D., Purohit D. M.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 49
167--171
EN
2-(4'-chlorophenyl)-6-methyl- (3-N, N'- diaryl/dialkyl amino methyl)-imidazo [1, 2-a] pyridine (4a-4l) has been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.
4
Content available remote Synthesis and Biological Screening of 3-Aryl-5-[(4′- difluoromethoxy)(3′-hydroxy)phenyl]-4,5-dihydro isoxazole
Bhadani V. N., Purohit H. D., Purohit D. M.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 47
133--138
EN
Isoxazoline derivatives shows various types of therapeutic activities like antimicrobial[1], antiinflammatory[ 2], anticonvulsant[3], Hypoglycemic[4] etc. getting to synthesized in view of 3-Aryl-5[(4′-difluoromethoxy)(3′-hydroxy)phenyl]-4,5-dihydro isoxazole (4a-4i) have been synthesized. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, M. luteus (Gram-positive bacteria), E. coli, S. thyphi (Gram-negative bacteria) and antifungal activity against Candida albicans (Fungi). The biological activities (MIC) of the synthesized compounds were compared with known standard drugs.
5
Content available remote Synthesis and Antimicrobial Screening of 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo[1, 2-a]pyridine -3-yl]-6"-aryl-4"-H-pyran-3"- Carbonitrile
Bhuva V. V., Bhadani V. N., Purohit H. D., Purohit D. M.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 49
149--154
EN
3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4"-H-pyran-3"- carbonitrile ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/mL. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.
6
Content available remote Synthesis and Antimicrobial Activity of [2"-aryl(quinoxaline)-3-yl]-(methylene phenyl amino)-6-[bis-(2"'-chloro ethyl) amino]-4-Methoxy-1,3,5-Triazine
Kathiriya P. J., Purohit H. D., Purohit D. M.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 49
130--136
EN
The compounds 5d, 5e, 5g, 5i showed moderate antimicrobial activity then other synthesized compounds, compare with known standard drugs.
7
Content available remote Synthesis and Antimicrobial Activity of 2-{4'-[(6"-aryl)2"-hydroxy-3",4"-dihydro-pyrimidine-4"-yl]-phenyl amino}-6-[bis (2'"-chloroethyl) amino]-4-Methoxy-1,3,5-Triazine
Kathiriya P. J., Purohit H. D., Purohit D. M.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 49
137--142
EN
The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]-Phenyl amino}-6-[bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with urea in presence of conc. HCl (0.3ml) The biological activities of these compounds have been examined against various Gram +ve, Gram –ve bacteria and fungi. The structure of the products was confirmed by IR, 1H NMR, Mass spectra and elemental analysis.
8
Content available remote Synthesis and Antimicrobial Activity of (1-acetyl/1-phenyl)-3-{4'-[(4'''-chlorophenyl) (phenyl) methyl amino] phenyl}-5-Aryl-Pyrazoline
Guna J. V., Bhadani V. N., Purohit H. D., Purohit D. M.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 49
104--108
EN
1-Acetyl-3-{4'-[(4'''-chlorophenyl) (phenyl) methyl amino] phenyl}-5-aryl-pyrazolines (3a-3l) and 1-Phenyl-3-{4'-[(4'''-chlorophenyl) (phenyl) methyl amino] phenyl}-5-aryl-pyrazolines (4a-4l) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram -ve bacteria and fungi. Some of the compounds showed moderate activity in concentration 50 μg/ml. The structure of the products have been elucidated by IR, 1H-NMR, mass spectral data elemental analysis and Thin layer chromatography.
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