Wyniki wyszukiwania - BazTech

1

Kinetic methods of determination of atenolol in pure compound and in pharmaceutical formulations

Hiremath G. C., Mulla R. M., Nandibewoor S. T.

Chemia Analityczna

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2005

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Vol. 50, No. 2

449-455

EN

A sensitive and rapid kinetic method for the determination of atenolol in bulk drugs, pharmaceutical preparations, and urine and blood samples has been developed. The method is based on the oxidation of atenolol by permanganate in alkaline media. The results were compared with the values obtained with the official method. The differences between them were statistically insignificant, as t- and F-tests have revealed. No interference from the commonly used excipients was observed.

PL

Opracowano czułą i szybką kinetyczną metodę oznaczania atenololu w substancji i w formie farmaceutycznej oraz we krwi i w moczu. Metoda jest oparta na utlenianiu atenololu nadmanganianem w środowisku alkalicznym. Wyniki otrzymane za pomocą proponowanej metody porównano, używając statystycznych testów Studenta (t) i Fishera (F), z wynikami otrzymanymi oficjalnie przyjętą metodą. Obie metody dały zgodne rezultaty. Nie zaobserwowano interferencji ze strony popularnych farmaceutycznych substancji pomocniczych.

2

Kinetics of oxidative degradation of threonine by alkaline permanganate

Mavalangi S. K., Pol P. D., Nandibewoor S. T.

Bulletin of the Polish Academy of Sciences. Chemistry

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2003

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Vol. 51, No. 3-4

181-193

EN

The kinetics of oxidation of threonine by permanganate in alkaline medium at a constant ionic strength has been studied spectrophotometrically. The reaction between permanganate threonine in alkaline medium exhibits 1:2 stoichiometry (KMnC>4: threonine). The reaction shows first order dependence of rate on permanganate concentration and less than unit order dependence each in threonine and alkali concentrations. Reaction rate increases with an increase in ionic strength and a decrease in solvent polarity of the medium. Initial addition of reaction products did not affect the rate significantly. A mechanism involving the formation of an intermediate complex between oxidant and substrate has been proposed. The rate constants and the activation parameters for the slow step of the mechanism have been evaluated and discussed.

3

Kinetics and mechanism of oxidation of L-phenylalanine by alkaline permanganate

Panari R.G., Chougale R.B., Nandibewoor S.T.

Polish Journal of Chemistry

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1998

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Vol. 72, nr 1

99-107

EN

The data suggest that the oxidation of L-phenylalanine proceeds via the formation of a complex between L-phenylalanine and permanganate which decomposes slowly, followed by a fast reaction between the free radical of L-phenylalanine and another molecule of permanganate to give the products. The reaction constants involved in the mechanism are derived. There is a good agreement between the observed and calculated rate contants at varying conditions of experiments. The activation parameters are computed with respect to the slow step of the mechanism.