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HPLC analysis in drug level monitoring of K027

Nurulain S. M., Kalász H., Szegi P., Kuca K., Adem A., Hasan M. Y. B., Hashemi F., Tekes K.

Acta Chromatographica

2013

Vol. 25, no. 4

703--710

HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.