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PL
W artykule przedstawiono algorytm FT-DSRR (Fault-Tolerant Desynchronized Static Round Robin-Robin Dispatching) pozwalający na planowanie przepływu komórek w polu Closa typu SMM (Space- Memory-Memory) z uszkodzeniami w punktach komutacyjnych. Uszkodzenia punktów komutacyjnych mogą pojawiać się na skutek promieniowania kosmicznego w polach komutacyjnych wykorzystywanych w systemach satelitarnych. W artykule przedstawiono wyniki badań symulacyjnych dotyczących wpływu liczby uszkodzeń, ich umiejscowienia oraz liczby komutatorów w drugiej sekcji pola na opóźnienie transmisji komórek i przepustowość pola SMM.
EN
In this paper a fault-tolerant desynchronized static round-robin (FT-DSRR) cell dispatching algorithm is presented. This algorithm was proposed for onboard SMM (Space-Memory-Memory) Clos-network switches with serious crosspoint faults caused by the harsh space radiation environment. The influence of the crosspoint faults on the average cell delay and throughput of the SMM Closnetwork switch depending on the total number of faults, their location within the SMM network, and the number of switches in the second stage was evaluated using computer simulation. Selected results are presented in the paper.
EN
This paper presents a method for designing a sliding mode control system for a second-order dynamic plant. Methods to eliminate the chattering effect and the simulation results are discussed.
PL
W artykule przedstawiono zagadnienia prognozowania oraz potrzeby jego stosowania w życiu codziennym. Przedstawiono również modele prognozujące stan wody na rzece Mała Panew zaprojektowane w systemie Predyktor. W artykule dokonano również analizy uzyskanych wyników prognoz.
EN
This paper presents the issues of forecasting and the need for its use in everyday life. It also presents the water level forecasting models on the Mala Panew River designed in the “ Predyktor” system. In this article was also presented ​​an analysis of the obtained forecasting results.
EN
This articlc contains information about the selectcd control methods. It describes the use of the PID controller in the aerodynamic two-rotor system. It also contains comparative analysis of two methods for PID control.
PL
Zbadano retencję i rozdzielenie na enancjomery serii 15 racemicznych pochodnych pirolidyn-2-onu w kolumnie tri(3,5-dimetylolfenylokarboilo)-β-cyklodekstrynowej, stosując zróżnicowany skład fazy ruchomej z jednym lub z dwoma modyfikatorami w układzie fazy normalnej, w fazie odwróconej i w fazie organicznej. Jako modyfikatory w układzie faz normalnych stosowano mieszaninę n-heksanu z etanolem lub 2-propanolem, w układzie faz odwróconych wodę z acetonitrylem, a w polarnej fazie organicznej acetonitryl z kwasem octowym lub acetonitryl z kwasem octowym i trietyloaminą. Zamiana układu faz normalnych na fazy odwrócone spowodowała zmianę kolejności elucji badanych związków. W układzie faz normalnych mieszanina n-heksanu z etanolem powoduje lepsze rozdzielenie enancjomerów niż mieszanina n-heksanu z 2-propanolem. Retencja i enancjoselektywność zależą od pH fazy ruchomej w układzie faz odwróconych. Lepszą separację enancjomerów uzyskano przy niskim pH (ok. 3). Niewielki dodatek trietyloaminy jako drugiego modyfikatora zwiększył sprawność układu i wpłynął na rozdzielenie enancjomerów trzech badanych związków. Znaczący wpływ achiralnych modyfikatorów na rozdział enancjomeskazuje na występowanie silnie zróżnicowanych oddziaływań międzymolekularnych w badanych układach. Podobny wniosek można było wysnuć na podstawie analizy równań QSRR.
EN
Fifteen racemic derivatives of pyrrolidin-2-one were sepd. on a tri(3,5-dimethylphenylcarboilo)-β-cyclodextrin column by using n-hexane/EtOH or n-hexane/Me₂CHOH in normal mobile phases, H₂O/MeCN reversed phases and MeCN/AcOH or MeCN/AcOH/Et₃N org. phases. EtOH was more efficient than Me₂CHOH in normal phases. The addn. of Et₃N resulted in an improvement of sepn. in reversed phase, where the best results were achieved at pH 3.
EN
This paper describes the issue of forecasting and the need for its use in everyday life. Also, the "Predyktor" system is described as a simple and effective tool for the design and analysis of forecasting models. In addition, the paper presents examples of forecasting models, developed in this system and it performs an analysis of the obtained forecast results.
EN
Syn the ses of 3,3- and 4,4-alkyl-phenyl-substi tuted pyrrolidin-2-one derivatives are described. The final compounds were obtained by the reductive cyclization of relevant cyanoalkanoate esters using NaBH4 and CoCl2×6H2O. The obtained pyrrolidin-2-one derivatives are pharmacophoric fragments for the syn thesis of various biologically active compounds.
8
Content available remote The role of biomechanics in orthopedic and neurological rehabilitation
EN
Movement is fundamental to human well-being, function and participation in work and leisure activities. As a result, regaining optimal movement abilities and independence frequently become central foci of rehabilitation programs developed for individuals recovering from serious orthopedic and neurologic injuries. Further, preventing additional injury to the locomotor system becomes essential for effective long-term management of chronic medical conditions such as tendon dysfunction and diabetes. The primary aim of this perspective is to illustrate the role of biomechanics in orthopedics, musculoskeletal and neurological rehabilitation. Specifically, this paper discusses selected examples, ranging from the tissue to whole body biomechanics level, that highlight how scientific evidence from the theoretical and applied sciences have merged to address common and sometimes unique clinical problems.
EN
The action of three functional rockers, namely the heel, ankle and forefoot rocker, assist the progression of the leg over the supporting foot. The purpose of this case series was to analyze the occurrence of foot rockers during gait in three children with cerebral palsy (CP) who had undergone the tendo-Achilles lengthening (TAL), procedure followed by a clinic- or home-based intervention and in one child with CP without history of surgery. Self-selected gait was video-recorded in a laboratory during six testing sessions at half-year intervals rendering a 3 year period of observation. One child had pre- and post-surgical gait data and the other two had post surgical data only. Sagittal plane knee angular velocity, as well as foot to ground positions, and foot rocker occurrence were analyzed. In a child with history of CP, and without history of surgery, mean angular velocities of the 1st, 2nd and 3rd foot rocker were 3.7, 0.57 and 6.67 rad/s, respectively, and the step length and cadence were normal. In children who underwent TAL the 1st and 2nd rocker was absent, as the initial contact of the foot with the ground was either with foot-flat or forefoot. The mean velocity of the 3rd rocker in children who underwent TAL was lower by approximately 50–80% than that of the nonsurgical case. Furthermore, the characteristic pattern of the knee joint to foot–floor position during gait was not observed in these cases. Foot rocker analysis identified children with abnormal gait characteristics. Following surgery these gait characteristics remained abnormal.
EN
The asymmetric synthesis of 1-{2-hydroxy-3-[4-(2-hydroxy-phenyl)-piperazin-1-yl]- propyl}-pyrrolidin-2-one 3 is described. Enantiomers of compound 3 were synthesized by hydrolytic kinetic resolution (HKR) of racemic 1-oxiranylmethyl-pyrrolidin-2-one rac-2 using soluble or polystyrene bound salenCo(III)OAc complexes folowing its aminolysis with 1-(2-hydroxy-phenyl)-piperazine. The enantiomeric purity of obtained dihydrochloride salts of compounds 3was determined by HPLC method with Chiralpack IA column. The ees determined for enantiomers of compound 3 were in range 92–96% and indicated that proposed methods are effective tools for the synthesis of aminoalcohols. The application of polystyrene bound catalyst of HKR enables its easy isolation from reaction mixture and recovery.
11
Content available remote Poszukiwanie nowych selektywnych antagonistów receptorów α1 adrenergicznych
EN
α1,-Adrenergic receptors (α1-AR) are members of the superfamily of G protein coupled receptors that transduce signals across the cell membrane. α1-ARs are comprised of multiple subtypes that have been identified by both pharmacological and binding studies [1], To date, they are classified into α1A, α1B, and α1D and the corresponding cloned counterparts termed α1a, α1b, and α1dAR, respectively. These subtypes have different tissue distributions with the α1A receptors predominating in lower urinary tract tissue, whereas this receptor subtype is less prevalent in the vasculature [2-4]. In recent years, the search for new selective α1-AR antagonists has intensified, due to their importance in the treatment of hypertension and of benign prostatic hyperplasia (BPH) [5-7]. Tamsulosin, the first α1A-AR „selective” antagonists for the treatment of BPH, was approved in 1997 [9, 12], A number of α1A subtype selective antagonists representing different structural classes of compounds were disclosed recently. These include: quinazolines [8-13], phenylalkylamines [9, 12, 14], piperidines [9, 15-23], arylpiperazines [24-36] and related compounds [37, 38], A review on the development of α1, selective antagonists are presented.
12
Content available remote Predictive torque equations for joints of the extremities
EN
The purpose of this study was to develop regression equations predicting torque output throughout the range of motion for the human elbow, shoulder, knee, and hip. Twenty-two healthy males participated. Torque values throughout the sagittal plane range of motion (i.e., flexion and extension) of the right elbow, shoulder, knee and hip were recorded (isokinetic dynamometer, 1 rad/sec) and expressed as a percentage of the peak torque produced for each motion. For each joint tested, regression equations based on ensemble-averaged, normalized torque data were calculated to predict the relative torque throughout the investigated range of motion when torque in one angular position was known. Shoulder flexion was best described by a second-order polynomial, while shoulder extension, elbow and knee flexion and extension, and hip flexion were described best by third-order polynomials. Hip extension was best described by a fourth-order polynomial. The regression multiple R2 values ranged between 0.998 and 1.000. These regression equations can be used to predict the expected torque anywhere in the sagittal plane range of motion based on knowledge of a torque recorded at another joint angle for the elbow, shoulder, knee, or hip joint. These equations can be used in the clinical setting when a direct examination of strength capability is not possible due to limitations in equipment or due to the presence of pain within the arc of motion.
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