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1 2020

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Asymetryczna aminokataliza : użyteczne narzędzie w tworzeniu chemicznej różnorodności

Skrzyńska Anna, Przydacz Artur, Dyguda Mateusz, Topolska Aleksandra, Albrecht Łukasz

Wiadomości Chemiczne

2020

[Z] 74, 3-4

255--284

Over the last 20 years asymmetric aminocatalysis has emerged as highly useful and reliable method of asymmetric synthesis. It involves the use of primary or secondary amines as catalysts of various stereoselective transformations of carbonyl substrates. Owing to the diverse activation strategies available in asymmetric aminocatalysis, it became a method of choice when the functionalization of prochiral aldehydes and ketones is considered. As a consequence, a direct and straightforward access to various chiral building blocks is possible that is of relevance to modern stereocontrolled organic synthesis. In the manuscript, the development of various aminocatalytic activation concepts is described and recent, selected contributions to this field of chemistry discussed. Main advantages of these strategies are highlighted providing an overview of this fascinating area of research.