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1 2019

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Nowe rozwiązania i modyfikacje najpopularniejszych polimerowych nośników substancji aktywnych

Odrobińska Justyna, Neugebauer Dorota

Wiadomości Chemiczne

2019

[Z] 73, 9-10

481--501

The progress of medicine and cosmetology corresponds to the increase in the need for new drug design and delivery methods, due to the already common cancer risk, as well as other diseases, which are still difficult for curing. Regardless of the type of active substance and its final application, the selection and synthesis of the appropriate carrier is crucial to provide the pharmaceutics to the target with the controlled release for a set period of time, including the intelligent activity. Depending on the way the bioactive substance is bound to carriers in the drug delivery systems (DDS) they are classified onto: carriers that physically encapsulate them inside i.e. liposomes, solid lipid nanoparticles, nanostructural lipid carriers, nanoparticles (nanocapsules, nanospheres), micelles, and carriers that chemically bind the active substance, i.e. conjugates, polyplexes. The current studies are emphasized to achieve the most perfect improvement, which concerns the efficiency of encapsulation, the ability to deliver several compounds simultaneously or sequentially, the productive release, the elimination of side products, the replacement of synthetic polymers by natural, biodegradable, biocompatible and non-toxic polymers. These carriers are also developed in terms of sensitivity to stimuli (one or several simultaneously or sequentially activated) and adapted for combined therapy. Although the subject of active substance delivery with the use of carriers is already widely studied, these are still a needs for the designing of new or the enhancement of the already known DDS. Working on this issue there is hope that today still incurable diseases, neoplastic diseases, as well as the diagnosis of these diseases themselves, will be possible to control and treat in the future. This report presents the current state of the knowledge in the area of DDS, focusing on newly developed solutions in the last years.