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Direct separation of clopidogrel enantiomers by reverse-phase planar chromatography method using β-cyclodextrin as a chiral mobile phase additive

Antic D., Filipic S, Ivkovic B., Nikolic K, Agbaba D.

Acta Chromatographica

2011

Vol. 23, no. 2

235--245

A simple and rapid TLC method using β-cyclodextrin as a chiral mobile phase additive (CMPA) was developed for direct separation of S-clopidogrel and its impurity R-clopidogrel. The influence of different factors (stationary phases, organic modifiers, chiral selectors and their concentrations in the mobile phase, and optimal saturation time of the chamber) on enantioseparation was studied. The best resolution of clopidogrel enantiomers was achieved on Polygram®cel 300 Ac-10% plates using isopropanol-0.5 mM β-cyclodextrin (6:4, υ/υ) as mobile phase in TLC chamber previously equilibrated with the mobile phase for 20 min. The spots were detected under UV light and using iodine vapours. The method enables rapid separation of clopidogrel enantiomers and can be successfully used in control of stereoselective synthesis of clopidogrel and in control of its purity. Finally, the molecular modelling of the inclusion complexes between the analytes and α-, β-, and γ-cyclodextrin was performed to investigate the mechanism of the enantiorecognition.

The Trobological properties of the new class of semi-synthetic cutting fluids for machining of aluminium alloys

Radijevic R., Milic R., Radojcic M., Ivkovic B.

Tribologia

2000

nr 2

199-204

The authors present a new semi-synthetic cutting fluid (CF) for machining of aluminium and its alloys. Development of this kind of cutting fluids is a consequence of growing application of aluminium and its alloys for machine parts. The friction and wear tests were performed using a block-on-disk type tribotester. The new cutting fluid has better tribological properties than the existing one used in the industry. Investigations conducted under production conditions of the developed product are in progress.

Autorzy prezentują nowy półsyntetyczny płyn obróbkowy przeznaczony do obróbki aluminium i jego stopów. Rozwój tej klasy płynów obróbkowych jest konsekwencją rosnącego zastosowania stopów aluminium na części maszyn. Badania tarcia i zużycia przeprowadzono na testerze rolka -klocek.Nowy płyn obróbkowy charakteryzuje się lepszymi właściwościami tribologicznymi niż obecnie stosowane w przemyśle. Badania w warunkach produkcji opracowanego produktu są w toku.