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Combined BNCT and PET for theranostics

Silarski Michał, Dziedzic-Kocurek Katarzyna, Szczepanek Monika

Bio-Algorithms and Med-Systems

2021

Vol. 17, no. 4

293--300

This short review summarizes the issue of boron distribution monitoring in boron neutron capture therapy (BNCT), which remains a serious drawback of this powerful oncological treatment. Here we present the monitoring methods that are presently used with particular emphasis on the positron emission tomography (PET) which has the highest potential to be used for the realtime monitoring of boron biodistribution. We discuss the possibility of using present PET scanners to determine the boron uptake in vivo before the BNCT treatment with the use of p-boronphenylalanine (BPA) labeled with 18F isotope. Several examples of preclinical studies and clinical trials performed with the use of [18F]FBPA are shown. We also discuss shortly the perspectives of using other radiotracers and boron carriers which may signifi- cantly improve the boron imaging with the use of the state-of-the-art Total-Body PET scanners providing a theranostic approach in the BNCT.

Hazardous Substance Detection in Water Environments using Neutron Beams : the SABAT Project

Silarski Michał

Problemy Mechatroniki : uzbrojenie, lotnictwo, inżynieria bezpieczeństwa

2019

Vol. 10, Nr 3 (37)

49--60

The ever-increasing risk of terrorist attacks is a stimulus for seeking new, more effective danger detection methods. The article describes new methods of detecting hazardous materials based on the interaction between neutrons and matter. The status of the design of the device for detecting hazardous materials in water environments based on these methods, currently in development at the Jagiellonian University (Kraków, Poland), will be presented as well.

Wciąż rosnące ryzyko ataków terrorystycznych skłania do poszukiwania nowych, efektywniejszych metod wykrywania zagrożeń. W artykule opisane zostaną nowe metody wykrywania materiałów niebezpiecznych, których podstawę stanowi oddziaływanie neutronów z materią. Przedstawiony zostanie również status projektu urządzenia do wykrywania materiałów niebezpiecznych w środowisku wodnym opartego na tych metodach, które jest rozwijane na Uniwersytecie Jagiellońskim.