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1

Farmakologiczna aktywność flawonoidów i aminoflawonów

Szeliga D., Korabik M., Ochocki J.

Wiadomości Chemiczne

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2018

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[Z] 72, 7-8

563--583

EN

Aminoflavones belong to a group of flavonoids, compounds commonly found in nature. Their pharmacological and biochemical effects include cytotoxic, antioxidant and antitumor properties. The studies have shown that complexes of aminoflavons with metal ions can be potential drugs and seem to be promising in the treatment of ovarian cancer, breast cancer, lung adenocarcinoma and melanoma. In addition aminoflavones have a lower cytotoxic activity towards healthy cells than another compounds. In the view of their wide pharmacological and biological actions, they seem to have great therapeutic potential.

2

Crystal structure and spectroscopic properties of [Zn(2-qmpe)Cl2] containing diethyl (quinolin-2-ylmethyl)phosphonate ligand (2-qmpe)

Żurowska B., Białońska A., Kotyński A., Ochocki J.

Materials Science Poland

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2010

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Vol. 28, No. 2

573--581

EN

The crystal structure of [Zn(2-qmpe)Cl2] (2-qmpe, diethyl (quinolin-2-ylmethyl) phosphonate) ligand) was determined by X-ray-diffraction. The compound was also characterized by IR, far-IR, 1H and 31P NMR spectroscopy. In the molecule, 2-qmpe acts as a bidentate N,O-chelate ligand. Tetrahedral ZnNOCl2 environment of Zn(II) atom is slightly distorted. The structure is stabilized by intermolecular H bond and n---n interactions. The spectral features are in agreement with the structural data.

3

Coordination properties of diethyl (pyridyn-2-ylmethyl)phoshate ligand with chloride transition metal salts

Żurowska B., Kalinowska-Lis U., Ochocki J.

Materials Science Poland

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2010

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Vol. 28, No. 3

749--755

EN

A new series of chloride transition metal complexes containing a diethyl (pyridyn-2-ylmethyl) phosphate (2-pmOpe) ligand, of the general formula [M(2-pmOpe)2Cl2] (M = Cu, Ni, Mn) and [M(2-pmOpe)Cl2] (M = Co, Zn), were synthesized and studied. The stoichiometry and stereochemistry of the compounds were confirmed by elemental analysis, spectroscopic and magnetic studies. The ligand containing two donor atoms, heterocyclic pyridyl nitrogen and phosphoryl oxygen atoms, binds in a didentate chelate manner in all complexes. The octahedral (Cu, Ni, Mn) and tetrahedral (Co, Zn) coordination sphere complete chloride ions included in coordination. The magnetic behaviour (for paramagnetic centres) and spectroscopic analyses of the complexes indicate a mononuclear structure and suggest existence of a very weak exchange coupling between the metal centres in the crystal lattice.

4

Structure and characterization of copper(II) perchlorate with diethyl(pyridin-2-ylmethyl) phosphonate (2-pmpe) ligand: [Cu(2-pmpe)2(ClO4)2]

Żurowska B., Białońska A., Ochocki J.

Materials Science Poland

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2009

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Vol. 27, No. 4/1

987--998

EN

Copper(II) mononuclear compound [Cu(2-pmpe)2(ClO4)2] (2-pmpe = diethyl(pyridin-2-ylmethyl) phosphonate was synthesized and studied. Examination of the crystal structure by the X-ray diffraction method revealed two crystallographically unrelated molecules, [Cu(1)(2-pmpe)2(ClO4)2] (1) and [Cu(2)(2-pmpe)2(ClO4)2] (2) in an asymmetric part of the unit cell. The geometry about the Cu(1) and Cu(2) chromophores shows elongated octahedra, resulting from the didentate N,O-bonded two chelate 2-pmpe ligands and two coordinated perchlorate ions around the Cu(II) cations (CuN2O4 chromophore). Similarly to 1, molecules 2 are linked to each other by weak C-HoooO hydrogen bonds and ?ooo? stacking interactions. Additionally, both 1 and 2 molecules are linked to each other through weak C-HoooO hydrogen bonds and C-Hooo? contacts, resulting in a 3D polymeric network arrangement. Magnetic data indicate a very weak intermolecular exchange interaction between copper(II) ions (zJ´ = -0.20 cm-1) transmitted through non-covalent interactions in the crystal lattice. The spectral properties are in accordance with the structural and magnetic data.

5

Coordination properties of the diethyl (pyridin-3-ylmethyl)phosphonate ligand (3-pmpe) with nitrate transition metal salts

Żurowska B., Kotyński A., Ochocki J.

Materials Science Poland

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2009

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Vol. 27, No. 4/1

999--1007

EN

A new series of nitrate transition metal complexes containing diethyl(pyridin-3-ylmethyl)phosphonate (3-pmpe) as a ligand, having a general formula [M(3-pmpe)2(H2O)2](NO3)2 (M = Cu, Co and Ni) and [Zn(3-pmpe)2](NO3)2 were prepared. The complexes were identified and characterized by the elemental analysis, spectroscopic and magnetic studies. Ligands containing two donor atoms, heterocyclic nitrogen and phosphoryl oxygen atoms bind in a bidentate bridging manner via the pyridine nitrogen and the phosphoryl oxygen atoms. The magnetic behaviour in the temperature range 1.8-300 K) of the Cu(II), Ni(II), Co(II) complexes as well as their spectroscopic properties suggest polymeric structure of all complexes and the existence of a weak antiferromagnetic exchange coupling between paramagnetic centres inside the dibridged linear chains [M(3-pmpe)2M]n.

6

Coordination properties of the diethyl 2-quinolilmethylphosphonate ligand with chloride and nitrate transition-metal salts

Żurowska B., Mroziński J., Ochocki J.

Materials Science Poland

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2007

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Vol. 25, No. 4

1063--1074

EN

A new series of the chloride and nitrate transition metal complexes containing the ligand diethyl 2-quinolylmethylphosphonate (2-qmpe) of general formula M(2-qmpe)(NO3)2 (M = Cu, Co), [Zn(2-qmpe)(H2O)2NO3]NO3ź H2O, [Ni(2-qmpe)(H2O)2NO3]NO3, M(2-qmpe)2Cl2 (M = Cu, Ni, Co, Pd) and M(2-qmpe)Cl2 (M = Co, Zn) were prepared. The complexes were identified and characterized by elemental analysis, spectroscopic and magnetic studies. Ligand containing two donor atoms, heterocyclic nitrogen and phosphoryl oxygen atoms exhibits different coordination properties. It was shown that the ligand binds in a bidentate chelate manner via the quinoline nitrogen and the phosphoryl oxygen atoms (complexes with 1:1 metal to ligand molar ratio) and it can also acts as a monodentate ligand coordinated through the nitrogen in the Pd(II) or oxygen atom in the Cu(II) and Co(II) complexes (complexes with 1:2 metal to ligand molar ratio). The magnetic behaviour of the Cu(II), Ni(II) and Co(II) and spectroscopic investigation of Zn(II) complexes suggests mononuclear structure of all the complexes and the existence of a weak intermolecular exchange coupling between magnetic centres inside crystal lattice.

7

Convenient Synthesis of Phosphonate Derivatives of 4-Chloro-2H-chromenes

Modranka R., Ochocki J.

Polish Journal of Chemistry

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2004

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Vol. 78 / nr 7

943-950

EN

2,4-Dichloro-2H-chromene-3-carboxylates are formed in good yield in the condensation of the appropriate precursors with SOCl2. These derivatives readily react with trialkyl phosphites to produce 2-phosphonate derivatives of 4-chloro-2H-chromene- 3-carboxylates.

8

Complexes of uracil (2,4-Dihydroxypyrimidine) Derivatives. Part I. Cu(II), Ca(II) and MG(II) Coordination with Uracil and Related Compounds in Aqueous Solution

Kufelnicki A., Kupińska I., Jezierska J., Ochocki J.

Polish Journal of Chemistry

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2002

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Vol. 76 / nr 11

1559-1570

EN

Potentiometric pH studies were carried out on proton and metal (Cu(II), Ca(II) and Mg(II)) complexes of HL = uracil, thymine (5-methyluracil), 6-chloromethyluracil, 5-hydroxymethyluracil, 6-methyluracil and a diethyl 6-uracilmethylphosphonate derivative. For Cu(II) additional spectroscopic (absorption and EPR) measurements were carried out. The results have been compared with the literature data accessible only for uracil and thymine. A deprotonation of the ML complexes in a more basic solution was indicated, thus, extending the coordination mode proposed up to now for uracil and thymine. An electron withdrawing effect of substituents has been found for 6-chloromethyluracil and diethyl 6-uracilmethylphosphonate.