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Syntheses of N,S-Substituted 4-Chloro-2-mercapto-5-methylbenzenesulfonamide Derivatives with Potential Biological Activity

Pomarnacka E., Kornicka A., Bednarski P. J., Charkiewicz A.

Polish Journal of Chemistry

2009

Vol. 83, nr 1

65-73

The syntheses of N,S-substituted 4-chloro-2-mercapto-5-methylbenzenesulfonamide derivatives are described. The compounds 6-11, 14, 15 and 19-22 were tested for their in vitro anticancer activity against 9 human cancer cell lines. The most active compounds 6, 9 and 20 showed moderate cytotoxic activity and were approximately 5-fold less potent than cisplatin.