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1 2000

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Thin-layer chromatographic estimation of the lipophilicity of some metallic complexes of diclofenac with potential anti-inflammatory activity

Sârbu C., Demertzis M. A., Kovala-Demertzi D.

Acta Chromatographica

2000

No. 10

222-230

The relative lipophilicity of seven complexes of diclofenac sodium {[2-[(2,6-dichlorophenyl)amino]phenyl]acetate}, NaL, with Cu2+, Co2+, Ni2+, Mn2+, Fe3+, Fe2+ and Pd2+, with potential anti-inflammatory properties, have been determined by reversed-phase thin-layer chromatography on C18 and CN plates with water–methanol mixtures as mobile phases. The RF values of the compounds increased linearly with increasing concentra-tion of methanol in the mobile phase. Generally, the presence of a cation increases the lipophilicity, expressed as the intercept (RM0), in the same manner. This means that the lipophilic behavior of metallic complexes depends primarily on the structure of ligand, although a more lipophilic effect was observed for Fe2+, Ni2+ and Fe3+ on C18 plates and for Cu2+ and, again, Fe2+ and Pd2+ on CN plates.