Sodium fluoride (NaF) is an agent promoting bone formation around the hip implant and it can be used as an additive in poly(methyl methacrylate) (PMMA) bone cement. The influence of such an addition on the fatigue endurance of the material as used in biomedical applications was tested. Fatigue tests were performed to simulate the mode of loading that the cement mantle withstands in vivo. Tensile tests were conducted according to current standards and based on protocols being previously validated. The results obtained prove that the addition of NaF (12% in weight) to PMMA bone cement does not have any detrimental effect on the fatigue resistance of the material. This percentage is higher than that normally used for BaS04 that is added to PMMA as a radiopacifier. This latter addition was proved to reduce the fatigue resistance of the material.
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