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1 2008

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Spirometry: quantification of the shape of the maximal expiratory flow-volume curve

Gólczewski T., Lubiński W.

Biocybernetics and Biomedical Engineering

2008

Vol. 28, no. 3

17-25

The relationship between Forced Expiratory Volume in one second (FEV1) and the Forced Vital Capacity (FVC) is intensively used in diagnosing because of its quantitative description with the index FEV1/FVC. There is not such index for the relationship between airflows (Peak Expiratory Flow (PEF) and Maximal Expiratory Flow at xx% of FVC (MEFxx, where xx = 75, 50, 25%)). Our aim was to describe that relationship quantitatively with the angle alfa between the 4-dimensional vector F = [PEF, MEF75, MEF50, MEF25] and the plane determined by two reference vectors: the mean of such vectors for the young and elderly. The reference vectors were found with data for 1,120 males and 1,625 females - Polish (white) population, healthy, never-smoking, aged 18 - 85 yrs, who performed a technically adequate spirometry maneuver. Upper Limit of Normal (ULN) was determined with the linear regression of the 5th percentiles of alfa on age (0.074*age + 2.76). Such an ULN seems to well indicate both improper examination and non-healthy persons.