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1

A UHPLC–MS/MS method for the quantitation of olmutinib in rat plasma

Bao Su-su, Wen Jian, Liu Teng-hui, Zhang B., Wang Chen-chen, Hu Guo-xin

Acta Chromatographica

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2019

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Vol. 31, no. 2

105--108

EN

Olmutinib (Olita™) is an oral third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) which is used to treat non-small cell lung cancer (NSCLC). A simple, rapid, and sensitive method based on ultra-performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) has been developed for the determination of olmutinib. Sample preparation was performed following simple one-step protein precipitation with acetonitrile. Olmutinib and internal standard (dasatinib) were separated on an Eclipse Plus C18 RRHD (2.1 × 50 mm, 1.8 μm) column. The mobile phase consisted of acetonitrile–0.1% formic acid in water with gradient elution. A total run time of 1.7 min was achieved. Detection was performed on a positive-ion electrospray ionization mass spectrometer in multiple reaction monitoring (MRM) mode, using transitions of m/z 487.2 → 402.1 for olmutinib and m/z 488.2 → 401 for dasatinib (IS), respectively. The calibration curve (R2 = 0.999) was linear over the range of 1–500 ng/mL. The recovery of olmutinib ranged from 85.8% to 95.5%. This method can be applied to pharmacokinetic studies of olmutinib.

2

The cavitation nuclei transient characteristics of Lennard-Jones fluid in cavitation inception

Fu Q., Zhang B., Zhao Y., Zhu R., Liu G., Li M.

Polish Maritime Research

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2018

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S 2

75--84

EN

In the field of ocean engineering, cavitation is widespread, for the study of cavitation nuclei transient characteristics in cavitation inception, we applied theoretical analysis and molecular dynamics (MD) simulation to study Lennard-Jones (L-J) fluid with different initial cavitation nuclei under the NVT-constant ensemble in this manuscript. The results showed that in cavitation inception, due to the decrease of liquid local pressure, the liquid molecules would enter the cavitation nuclei, which contributed to the growth of cavitation nuclei. By using molecular potential energy, it was found that the molecular potential energy was higher in cavitation nuclei part, while the liquid molecular potential energy changes greatly at the beginning of the cavitation nuclei growth. The density of the liquid and the surface layer changes more obvious, but density of vapor in the bubble changes inconspicuously. With the growth of cavitation nuclei, the RDF peak intensity increased, the peak width narrowed and the first valley moved inner. When cavitation nuclei initial size reduced, the peak intensity reduced, the corresponding rbin increased. With the decrease of the initial cavitation nuclei, the system pressure and total energy achieved a balance longer, and correspondingly, they were smaller. In addition, at the beginning of the cavitation nuclei growth, the total energy and system pressure changed greatly.

3

Hydrodynamic load and parametric design of grouted clamp used on offshore jacket

Zhang B, Wang Z., Wang T.

Polish Maritime Research

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2018

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S 3

154--165

EN

The reliability and safety of offshore platform are an important research aspect in marine engineering. The jacket platform is mainly used for oil development and submarine drilling, and the long-term work in the marine environment will be subjected to different loads, which will lead to the damage of the structure part of the offshore platform. It affects the structural strength of the platform. For the repair of jacket damage, grouted reinforcement technology is adopted, which has the advantages of simple underwater installation and low cost. The reinforcement technology of the grout hoop has been applied to the engineering projects abroad, but the stress and serialization design of the hoop in the marine environment need further study. This paper will combine the ocean current and wave force to carry out the research of underwater work and prevent loosening, and put forward the parametric design method for the specific size of the hoop. Two types of experimental models are designed: short bolt form clamp and long bolt form clamp. The mechanical experiment of the long bolt clamp is carried out, and the relationship between the slipping force and the bolt preload is analyzed, so as to verify the theoretical analysis.

4

Decoupling control for permanent magnet in-wheel motor using internal model control based on back-propagation neural network inverse system

Li Y., Zhang B., Xu X.

Bulletin of the Polish Academy of Sciences. Technical Sciences

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2018

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Vol. 66, nr 6

961--972

EN

The permanent magnet in-wheel motor (PMIWM) is a nonlinear, multivariable, strongly coupled and highly complex system. The key to the development and application of the PMIWM consists in the improvement of its control accuracy and dynamic performance. In order to effectively decouple the PMIWM, this paper presents a novel internal model control (IMC) approach based on the back-propagation neural network inverse (BPNNI) control method. First, theoretical analysis is conducted to show the existence of the PMIWM inverse system, to be modeled mathematically. The inverse system approximated and identified by the back-propagation neural network (BPNN) constitutes the back-propagation neural network inverse (BPNNI) system. Then, by cascading the BPNNI system on the left side of the original PMIWM system, a new decoupling, pseudo-linear system is established. Moreover, the 2-DOF internal model control (IMC) method is employed to design the extra closed-loop controller that further improves disturbance rejection and robustness of the whole system. Consequently, the proposed decoupling control approach incorporates the advantages of both the BPNNI and the IMC. Effectiveness of thus proposed control approach is verified by means of simulation and real-time hardware-in-the-loop (HIL) experiments.

5

Satellite Orbit Determination using Quantum Correlation Technology

Zhang B., Sun F., Zhu X., Jia X.

Acta Geophysica

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2018

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Vol. 66, no. 2

233--241

EN

After the presentation of second-order correlation ranging principles with quantum entanglement, the concept of quantum measurement is introduced to dynamic satellite precise orbit determination. Based on the application of traditional orbit determination models for correcting the systematic errors within the satellite, corresponding models for quantum orbit determination (QOD) are established. This paper experiments on QOD with the BeiDou Navigation Satellite System (BDS) by first simulating quantum observations of 1 day arc-length. Then the satellite orbits are resolved and compared with the reference precise ephemerides. Subsequently, some related factors influencing the accuracy of QOD are discussed. Furthermore, the accuracy for GEO, IGSO and MEO satellites increase about 20, 30 and 10 times, respectively, compared with the results from the resolution by measured data. Therefore, it can be expected that quantum technology may also bring delightful surprises to satellite orbit determination as have already emerged in other fields.

6

Analysis and experiments on sea load and fastened mechanics on pipe clamps

Wang Z., Zhang B., Wang T.

Polish Maritime Research

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2017

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S 2

74--80

EN

When an offshore oil field completed and put into production, new subsea pipelines and the new cable need to be established. Cable protection pipe clamp is used to fix cable protection pipe on the jacket. In order to avoid the problem of traditional steel structure clamp splice, counterpoint, fastening difficulty when installed cable protection pipe under water, reduce the risk and workload of under water, This paper develop a new type of portable connecting riser clamp –“backpack clamp” which solve the riser cable protection pipe difficult underwater installation problem. The main structure of backpack clamp used three valves type structure. The load characteristic of a clamping device was determined by the Morison equation which was a classical theory. Clamp device underwater mechanics analysis model was established. The minimum tension pre-tightening force was determined. The results show that the strength of the base meets the requirements after strength analysis with finite element analysis method, stability and strength experiments, which means the clamp based on resin matrix composite is feasible.

7

Generation of cyber-security reinforcement strategies for smart grid based on the attribute-based attack graph

Zhang B., Li Q., Zhang Y., Liu X., Ni Z.

Journal of Power Technologies

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2016

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Vol. 96, nr 3

170--177

EN

A smart grid is a kind of energy cyber-physical system (ECPS) with the interdependency of information and physicality. A cyber-attack gravely threatens the safe and stable operation of a physical power grid. Cyber-security reinforcement of smart grid has become a research issue. However, the information network scale of a smart grid is massive, and the generation of security reinforcement strategies has become a problem. Therefore, a generation method of security reinforcement strategies based on an attribute-based attack graph was proposed in this study. The method defined a smart grid based on premise and consequence attributes to form an attribute-based attack graph. With this graph, the method for the generation of security reinforcement strategies was transferred to the minimum dominating set of the attribute-based attack graph and solved to realize space reduction in the security reinforcement strategies. An algorithm for the generation of security reinforcement strategies was designed based on the greedy algorithm, and strategies for large-scale cyber security reinforcement of the smart grid were determined to eliminate the complexity and difficulty of this problem effectively. Through a simulation analysis of a large-scale node network, the efficiency of the generation method of reinforcement strategies based on the attribute based attack graph and minimum dominating set was verified. Results show that the proposed method can be used for security reinforcement of large-scale complicated networks of a smart grid.

8

Measurement of the Indentation Modulus and the Local Internal Friction in Amorphous SiO2 Using Atomic Force Acoustic Microscopy

Zhang B., Wagner H., Büchsenschütz-Göbeler M., Luo Y., Küchemann S., Arnold W., Samwer K.

Archives of Metallurgy and Materials

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2016

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Vol. 61, iss. 1

9--12

EN

For the past two decades, atomic force acoustic microscopy (AFAM), an advanced scanning probe microscopy technique, has played a promising role in materials characterization with a good lateral resolution at micro/nano dimensions. AFAM is based on inducing out-of-plane vibrations in the specimen, which are generated by an ultrasonic transducer. The vibrations are sensed by the AFM cantilever when its tip is in contact with the material under test. From the cantilver’s contactresonance spectra, one determines the real and the imaginary part of the contact stiffness k*, and then from these two quantities the local indentation modulus M' and the local damping factor Qloc-1 can be obtained with a spatial resolution of less than 10 nm. Here, we present measured data of M' and of Qloc-1 for the insulating amorphous material, a-SiO2. The amorphous SiO2 layer was prepared on a crystalline Si wafer by means of thermal oxidation. There is a spatial distribution of the indentation modulus M' and of the internal friction Qloc-1. This is a consequence of the potential energy landscape for amorphous materials.

9

Design method of winch driven by contactless magnetic coupling under deepwater

Zhang B., Wang Z., Wang T., Yu H. J.

Polish Maritime Research

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2015

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S 1

95--99

EN

Through the combination subject of scientific research, the design method of the winch driven by contactless magnetic coupling is researched for the core purpose of the turning shaft sealing in a deepwater environment. This method has six design phases, including domestic and foreign information query and retrieval, graphic analyses of relevant structures, innovative design of 2D assembly sketches, a theoretical computation of structure parameters, the 3D modeling and motion simulation and engineering drawing. This method is of generality, which can provide examples for the postgraduate students and engineering personnel in self-renovation design of scientific research.

10

Wave propagation in functionally graded piezoelectric rods with rectangular cross-section

Yu J. G., Zhang B., Lefebvre J. E., Zhang Ch.

Archives of Mechanics

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2015

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Vol. 67, nr 3

213–-231

EN

For the purpose of design and optimization of functionally graded piezoelectric material (FGPM) transducers, wave propagation in FGPM structures has received much attention in the past twenty years. But research focused essentially on semi-infinite structures and one-dimensional structures, i.e., structures with a finite dimension in only one direction, such as horizontally infinite flat plates and axially infinite hollow cylinders. This paper proposes a double orthogonal polynomial series approach to solve the wave propagation problem in a two-dimensional (2D) FGPM structure, namely, an FGPM rod with a rectangular cross-section. The dispersion curves and electric potential distributions are illustrated.

11

Regional features analysis of plugged holes of dense phase gas-solid separation fluidized bed

Zhang B., Zhao Y., Luo Z., Song S., Duan C., Dong L.

Physicochemical Problems of Mineral Processing

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2014

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Vol. 50, iss. 2

667--679

EN

In contrast to traditional coal separation, dry separation does not require water and does not cause water pollution. Dense phase gas–solid fluidized beds are used for dry separation. The plugged holes in the air distributor should be tested to ensure the stability of these beds for particle separation. The pressure fluctuation is sensitive to these plugged holes. This sensitivity can be tested and diagnosed by determining the standard deviation of the pressure fluctuation. In areas with partial blockage, that is the areas with weak fluidization, a decrease in the volume fraction of the particles and in the pressure differences in the transverse of the bed results in an increase of the standard deviation of the pressure fluctuation, thereby stimulating the lateral mixing of medium-sized particles. The standard deviation and the mixing intensity decrease axially. The value of sensitivity of the plugged holes in the air distributor decreases as the height of the bed increases. The features of air distributors affect the surrounding areas. The distribution law determining the influence of plugged holes on the beds is symmetrical. As the blockage of the fluidized bed distributor region increases, the mean square error of the pressure fluctuation in the related regions increases. The intensity of the effect is proportional to the distance to the plugged holes.

12

Design of Fractional Order Sliding Mode Controller Based on Parameters Tuning

Zhang B., Pi Y.

Przegląd Elektrotechniczny

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2012

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R. 88, nr 10a

172-175

EN

For dealing with the chattering phenomenon existing in conventional first order sliding mode controller, in this paper, a fractional order sliding mode controller (FOSMC) is proposed. Based on the advantage of fractional order differential and integral calculus, the sliding mode surface is designed with fractional order differential but not integral order. Under the stable performance of system, the parameters of sliding mode surface are tuned by given crossover frequency and phase margin. Furthermore, the soft-switching gain is obtained used fuzzy logic inference system. Simulations and experiments demonstrate that the proposed fractional order sliding mode controller not only achieve high control performance, but also is robust with regard to external disturbance.

PL

W artykule zaproponowano ułamkowy sterownik ślizgowy FOSMC. Przy ustalonych parametrach systemu powierzchnia ślizgowa jest dobierana przez uwzględnianie częstotliwości i marginesu fazy. Przełączane wzmocnienie jest realizowane po zastosowaniu układu logiki rozmytej. Układ jest bardziej odporny na zewnętrzne zakłócenia. (Projekt sterownika ślizgowego ułamkowego rzędu bazujący na dobieraniu parametrów)

13

A compact cap-free headphone driver

Wang H., Zhang B., Sun J.

Przegląd Elektrotechniczny

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2012

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R. 88, nr 12a

333-337

EN

This paper proposes a compact structure to generate high rejection power supplies for proposed class AB amplifier (abamp). A NMOSbased low drop out regulator that does not require external compensation is utilized to provide a positive power supply. A regulated negative charge pump is utilized to provide a negative power supply. Chopper technology is utilized in the abamp to lower noise and offset. The driver could provide high power supply rejection (88dB at 217 Hz), high fidelity (74 dB total harmonic plus noise), low noise (7 μV) and low offset (1 mV) audio signals.

PL

W artykule zaproponowano kompaktową strukturę zasilacza ze sterownikiem o wysokiej skuteczności eliminacji szumów. W zasilaczu zastosowano tranzystor typu NMOS i sterowaną przetwornicę napięcia oraz chopper w celu redukcji szumów oraz offset-u.

14

Integration of Fuzzy and Sliding Mode Control Based on Fractional Calculus Theory for Permanent Magnet Synchronous Motor

Zhang B., Pi Y.

Przegląd Elektrotechniczny

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2011

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R. 87, nr 11

251-255

15

Laser diode array (LDA) end-pumped multi-watt Yb:YAG 1030 nm laser

Cao H., Peng H., Zhang M., Chen Y., Zhang B., Chen B., Zhang J., Wu T., Zhao X., Tan H.

Optica Applicata

|

2010

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Vol. 40, nr 3

653--656

EN

A LDA (laser diode array) end-pumped Yb:YAG 1030 nm laser is reported. Using a plano-concave resonator, with input pump power of 11.79 W, 2.55 W TEM00 continuous wave laser at 1030 nm was obtained. The effective focal length of the thermal lens is also calculated.

16

The Quotient Space Theory of Problem Solving

Zhang L., Zhang B.

Fundamenta Informaticae

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2004

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Vol. 59, nr 2,3

287--298

EN

The paper introduces a framework of quotient space theory of problem solving. In the theory, a problem (or problem space) is represented as a triplet, including the universe, its structure and attributes. The problem spaces with different grain sizes can be represented by a set of quotient spaces. Given a problem, the construction of its quotient spaces is discussed. Based on the model, the computational complexity of hierarchical problem solving and the information combination are also dealt with. The model can also be extended to the fuzzy granular world.

17

Feedback and pole assignment of the second order singular distributed parameter control systems

Ge Z., Zhang B.

Systems Science

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2003

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Vol. 29, nr 4

19-27

EN

Pole assignment for infinite many poles of the second order singular distributed parameter control system was discussed via functional analysis and operator theory in Hubert space. The solutions of the problem and the constructive expression of the solutions are given by the generalized inverse one of bounded linear operator. This research is theoretically important for studying the stabilization and asymptotic stability of the second order singular distributed parameter control system.

18

Natural stereospecific hydrogen isotope transfer in alcohol dehydrogenase-catalysed reduction

Zhang B., Pionnier S.

Nukleonika

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2002

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Vol. 47,suppl.1

29-31

EN

The enantiomeric purity of natural alfa-monodeuterated enantiomers, (R) and (S) ethanol-1-d1, in the alcohol produced by sugar fermentation with yeast was studied by 2H NMR using their esters derived from optical mandelic acid. The results of isotope tracing experiments show that the transfer pathways of the two enantiotopic hydrogens of the methylene group are different. It was observed that (S)-deuterium comes only from the medium water. The (R)-deuterium transfered by NADH in alcohol dehydrogenase reduction of the acetaldehyde is of complex origin. Some of them originates from carbon bound hydrogen of the sugar, especially from C(4) position of glucose and most of them comes from water. Only a small portion of the NADH deuterium is incorporated indirectly from water through enzyme catalysed exchange between the pro-S site of NADH and flavin. When a carbonyl compound (ethyl acetoacetate) was reduced under the same conditions during the alcoholic fermentation, among the NADH-transfered deuterium, only a small portion comes from water while most comes from the unexchangeable positions of the glucose.

19

Influence of the photosynthetic pathway on the hydrogen isotopic profile of glucose

Zhang B., Billault I., Li X., Mabon F., Remaud G., Martin M.

Nukleonika

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2002

|

Vol. 47,suppl.1

63-65

EN

The SNIF-NMR method (site-specific natural isotope fractionation studied by Nuclear Magnetic Resonance) was used to examine the isotopic profile of glucoses derived from plants with different photosynthetic pathways. It is shown that the type of photosynthetic metabolism, either C3 (beet-root, orange, grape), C4 (maize, sugar-cane) or CAM (pineapple), exerts a strong influence on the deuterium distribution in the sugar molecules. The isotopic profile also depends, secondarily, on the physiological status of the precursor plant. Consequently, the isotopic fingerprint of glucose may be a rich source of information in mechanistic comparisons of metabolic pathways. Moreover, from an analytical point of view, it may provide complementary criteria with respect to the ethanol probe for origin inference of sugars.