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1 2024

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Evaluation on safety and efficacy of ultrasound assisted thrombolysis in a sheep artificial heart pump

Cui Yongchun, Zheng Xiaobing, Wang Shuo, Zhou Jianye, Yue Guangxin, Peng Peng, Li Qiuju, Li Jubo, Li Yue, Luo Jiafei, Zhang Qi, Zhang Xue, Li Yongjian, Wang Xin

Biocybernetics and Biomedical Engineering

2024

Vol. 44, no. 2

277--285

Thrombosis is a major and serious complication in patients with artificial heart pump assist device (HPAD). There is an urgent need for an efficient and safe method to solve the clinical challenge. We have developed a new type of ultrasound integrated heart pump assist device (uHPAD) with a pair of ultrasonic transducer rings installed around the pump. Based on the in-vitro experiments, the sonothrombolysis protocol was determined. Then, in-vivo experiments were performed on sheep to evaluate the efficacy and safety of the novel uHPAD. It is found that the ultrasound assisted thrombolysis with the drug-loaded microbubbles can accelerate the dissolution of the thrombus in the pump, while have no significant negative effect on blood cell components, coagulation-hemolysis system, and the structure and function of main organs. The ultrasound assisted thrombolysis is demonstrated to be a promising method to solve the clinical problem of thrombosis in the HPAD.