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Urease Inhibitiory Flavone Glucosides from Marrubium anisodon

Hussain A., Perveen S., Malik A., Afza N., Iqbal L., Tareen R. B.

Polish Journal of Chemistry

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2009

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Vol. 83, nr 7

1329-1335

EN

Compounds 1–3, new flavonoid glucosides have been isolated from the ethyl acetate soluble fractions of Marrubium anisodon, along with apigenin 4'-O-beta-D-glucopyranoside 4, kaempferol 3-O-beta-D-glucopyranoside 5 and beta-sitosterol 3-O-beta-D-glucopyranoside 6, re - spectively. Their structures were as signed from 1H- and 13C-NMR spectra, DEPT and by COSY, HMQC, NOESY and HMBC experiments. Compounds 1–5 showed significant inhibitory activity against the enzyme urease.

2

Lipoxygenase Inhibitory Lignans from Salvia santolinifolia

Mehmood S., Riaz N., Ahmad Z., Afza N., Malik A.

Polish Journal of Chemistry

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2008

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Vol. 82, nr 3

571-575

EN

Santolinol, a new lignan has been isolated from the chloroform soluble fraction of Salvia santolinifolia and as signed the structure 1 on the basis of spectral studies including 2D NMR. In addition three bifuranolignans namely didemethylpinoresinol 2, (+) fraxiresinol 3 and (+) 1-hydroxysyringaresinol 4 have also been isolated for the first time from this species. All these compounds showed potent inhibitory potential against the enzyme lipoxygenase.

3

Butyrylcholinesterase Inhibitory Triterpenes from Salsola baryosma

Ahmad Z., Mehmood S., Ifzal R., Malik A., Afza N., Rashid F., Mahmood A., Iqbal L.

Polish Journal of Chemistry

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2007

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Vol. 81, nr 8

1427-1432

EN

Salsolic acid (1), a new oleanane type triterpene has been isolated from the chloroform soluble fraction of Salsola baryosmaalong with known triterpenes (2) and (3) isolated for the first time from this species. The compounds 1–3 showed inhibitory activity against the enzyme butyrylcholinesterase.

4

Iridoid Glucoside and Aryl Ester from Buddleja crispa

Ahmad I., Malik A., Afza N., Fatima I., Tareen R., Nawaz S., Choudhary M.

Polish Journal of Chemistry

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2006

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Vol. 80, nr 9

1483-1491

EN

Iridoid glucoside (1) and aryl ester (2) have been isolated from Buddleja crispa along with buddlejosides A2 (3) and A5 (4) isolated for the first time from this species. The structures of all of the compounds were determined by spectroscopic techniques and chemical studies. Compound 1 displayed lipoxygenase inhibitory potential with an IC50 value of 52.5 š 0.03 mi M while compound 2 inhibited acetylcholinesterase and butyrylcholinesterase enzymes with IC50 values of 36.5 š 0.03 mi M and 12.5 š 0.02 mi M, respectively.

5

Lipoxygenase Inhibiting Steroidal Glycosides and Naphthene Derivatives from Haloxylon salicornicum

Ferheen S., Ahmed E., Afza N., Malik A., Nawaz S., Choudhary M.

Polish Journal of Chemistry

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2005

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Vol. 79 / nr 9

1469-1476

EN

Allostigmasterol glycosides 1 and 2 and monocyclic naphthene derivatives 3 and 4 have been isolated from methanolic extract of Haloxylon salicornicum and their structures elucidated through spectroscopy. Triacontanoic acid 5, ergosterol peroxide 6 and lupeol 7 were also obtained for the first time from this species. Both 1 and 2 showed moderate lipoxygenase inhibiting activity.

6

Urease Inhibiting Guaianolides from Amberboa ramosa

Khan S., Riaz N., Afza N., Malik A., Azhar-ul-Haq, Ahmed Z., Lodhi M., Choudhary M.

Polish Journal of Chemistry

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2004

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Vol.78 /nr 11-12

2075-2080

EN

New sesquiterpene lactones have been isolated from the chloroform-soluble fraction of Amberboa ramosa and assigned two structures 4 beta-(chloromethyl)-3 beta, 4 alfa-dihydroxy, 8alfa-[(s)-2-carboxypropionoxy]-1alfaH,5alfaH,6betaH,7alfaH-guaia-10(14),11(13)-dien- 6,12-olide (1) and 4 beta(chloromethyl)-3beta ,4alfa-dihydroxy,8alfa-[(s)-3-hydroxy-2-methylpropionyloxy]- 1alfaH,5alfaH,6beta H,7alfaH-guaia-10(14),11(13)-dien-6,12-olide (2), respectively. In addition 5-hydroxy-6-methyl-7-methoxyflavone (3), 6,2',5'-trihydroxy-3,5,7-trimethoxyflavone (4) and 5-hydroxy-3,7,8,2'-tetramethoxyflavone (5) have also been reported for the first time from this species. Compounds 1 and 2 displayed promising inhibitory potential against enzyme urease in a concentration-dependent fashion.