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1 2008

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Validated HPLC method for analysis of oxaprozin in a formulation

Ganesh M., Thangabalan B., Patil R., Thakur D., Saravana Kumar A., Vinoba M., Ganguly S., Sivakumar T.

Acta Chromatographica

2008

Vol. 20, no. 2

165-173

A rapid, simple and validated reversed-phase high-performance liquid chromatographic method has been developed for analysis of oxaprozin in pharmaceutical dosage forms. Oxaprozin was separated on an ODS analytical column with a 45:55 (v/v) mixture of acetonitrile and triethanolamine solution (5 mM, pH 3.5 š 0.05, adjusted by addition of 85% phosphoric acid) as mobile phase at a flow rate of 2.0 mL min-1. The effluent was monitored by UV detection at 254 nm. Calibration plots were linear in the range 160 to 240 µg mL-1 and the LOD and LOQ were 14.26 and 41.21 µg mL-1, respectively. The high recovery and low relative standard deviation confirm the suitability of the method for routine QC determination of oxaprozin in tablets.