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2 Polish Journal of Chemistry

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Chiroptical Properties of the Guanidine Chromophore

Siemion I., Ślepokura K., Gawłowska M., Biernat M.

Polish Journal of Chemistry

2005

Vol. 79 / nr 2

401-412

The CD spectra of 15 alfa-guanidino-acids, derived from 15 proteinaceous amino acids were measured and analysed. Using L-amidino-proline, L-amidino-prolinol, and L-amidino- 4-hydroxyproline as standards the sector rule for prediction of the sign of the Cotton effect at 190-195 nm, attributed to the guanidine chromophore, was constructed. X-ray analysis of crystal structures of L-amidino-4-hydroxyproline and L-amidinomethionine was also performed.

Mycobacterium kansasii Phagocytosis Inhibition by the Oligopeptides Derived from Systemine, Cecropin A and BRCT-1 Protein Sequences

Siemion I., Gawłowska M., Wieczorek Z.

Polish Journal of Chemistry

2004

Vol. 78 / nr 8

1073-1079

In this work the results of investigations of the influence of three series of peptides on the inhibition of the Mycobacterium kansasii phagocytosis are presented. The peptides are the fragments of systemine (the plant signaling protein), antimicrobial peptide cecropine A, and the active fragment GRGDVVNGRG of the BRCT protein. It was found that KRDVY is a weaker inhibitor of phagocytosis than its analog RKDVY. Introduction of the sequence RDG in the place of RGD (present in cecropine A) decreases the antiphagocytic activity in comparison with the RGDVY peptide. Very interesting is a high biological activity of the palindromic peptide GRGNVVNGRG, while its parent peptide, indicated above, is inactive.