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1 2006

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Chiral high-performance liquid chromatographic method for enantioselective analysis of zaltoprofen

Nirogi R. V. S., Kota S., Peruri B. G., Kandikere V. N., Mudigonda K.

Acta Chromatographica

2006

No. 17

202-209

A simple reversed-phase chiral HPLC method has been developed and validated for direct separation of the enantiomers of zaltoprofen. Separation of the enantiomers was tested on numerous commercial chiral HPLC columns. Separation was best (resolution, RS = 3) on a Chiralcel OJ-RH stationary phase. Typical retention times of the S and R enantiomers were approximately 14 and 16 min, respectively. Mobile phase composition was systematically studied to find the optimum chromatographic conditions. Validation of the method under the conditions selected showed it was selective and precise and the detector response was a linear function of zaltoprofen enantiomer concentration.