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Breast cancer detection from histopathology images using modified residual neural networks

Gupta Varun, Vasudev Megha, Doegar Amit, Sambyal Nitigya

Biocybernetics and Biomedical Engineering

2021

Vol. 41, no. 4

1272--1287

Breast cancer is one of the major causes of death among women worldwide. Efficient diagnosis of breast cancer in the early phases can reduce the associated morbidity and mortality and can provide a higher probability of full recovery. Computer-aided detection systems use computer technologies to detect abnormalities in clinical images which can assist medical professionals in a faster and more accurate diagnosis. In this paper, we propose a modified residual neural network-based method for breast cancer detection using histopathology images. The proposed approach provides good performance over varying magnification factors of 40X, 100X, 200X and 400X. The network obtains an average classification accuracy of 99.75%, precision of 99.18% and recall of 99.37% on BreakHis dataset with 40X magnification factor. The proposed work outperforms the existing methods and delivers state-of-the-art results on the benchmark breast cancer dataset.

Modified U-Net architecture for semantic segmentation of diabetic retinopathy images

Sambyal Nitigya, Saini Poonam, Syal Rupali, Gupta Varun

Biocybernetics and Biomedical Engineering

2020

Vol. 40, no. 3

1094--1109

Segmentation of lesions from fundus images is an essential prerequisite for accurate severity assessment of diabetic retinopathy. Due to variation in morphologies, number and size of lesions, the manual grading process becomes extremely challenging and time-consuming. This necessitates the need of an automatic segmentation system that can precisely define the region of interest boundaries and assist ophthalmologists in speedy diagnosis along with diabetic retinopathy severity grading. The paper presents a modified U-Net architecture based on residual network and employs periodic shuffling with sub-pixel convolution initialized to convolution nearest neighbour resize. The proposed architecture has been trained and validated for microaneurysm and hard exudate segmentation on two publicly available datasets namely IDRiD and e-ophtha. For IDRiD dataset, the network obtains 99.88% accuracy, 99.85% sensitivity, 99.95% specificity and dice score of 0.9998 for both microaneurysm and exudate segmentation. Further, when trained on e-ophtha and validated on IDRiD dataset, the network shows 99.98% accuracy, 99.88% sensitivity, 99.89% specificity and dice score of 0.9998 for microaneurysm segmentation. For exudates segmen-tation, the model obtained 99.98% accuracy, 99.88% sensitivity, 99.89% specificity and dice score of 0.9999, when trained on e-ophtha and validated on IDRiD dataset. In comparison to existing literature, the proposed model provides state-of-the-art results for retinal lesion segmentation.