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Extraction protocol for isolation of CNSL by using protic and aprotic solvents from cashew nut and study of their physico-chemical parameter

Gandhi T. S., Dholakiya B. Z., Patel M. R.

Polish Journal of Chemical Technology

2013

Vol. 15, nr 4

24-27

Cashew nut shell liquid (CNSL) represents the largest readily available bioresource of alkenyl phenolic compounds. (CNSL) and its derivatives are widely used in polymer-based industries, synthesis of chemicals and intermediates, including bactericides, insecticides and surface active agents. In this work extraction of cashew nut shell liquid from cashew nut shell (CNS) was carried out by using the Soxhlet extraction method in the presence of polar & non-polar solvents. From the extracted CNSL, anacardic acid was selectively isolated and acid free CNSL was treated with liquor ammonia to separate the cardanol and cardol in the stepwise manner. Comparative study for the extracted CNSL and S-was performed. Higher amount of extracted CNSL was obtained from polar solvents. They were all characterized using quantitative analysis by HPLC.

HPTLc method development and validation for analysis of risperidone in formulations, and in-vitro release study

Patel R. B, Patel B. G, Patel M. R, Bhatt K. K

Acta Chromatographica

2010

Vol. 22, no. 4

549--567

A new, simple, and rapid high-performance thin-layer chromatographic method has been established for quantitative analysis of risperidone. Chromatography was performed on silica gel 60 F 254 plates with methanol-ethyl acetate 8.0:2.0 ( v / v ) as mobile phase. Risperidone was quantified by densitometric analysis at 285 nm. The method gave compact bands for the drug ( R F 0.34 ± 0.01). Linear regression analysis of calibration data revealed a good linear relationship ( r 2 = 0.9996) between response and amount of risperidone in the range 100–600 ng per band. The method was validated for precision, recovery, repeatability, linearity, specificity, and robustness in accordance with ICH guidelines. The minimum detectable amount was 22.44 ng per band and the limit of quantification was 68.01 ng per band. Statistical analysis of the results showed the method enabled precise, accurate, reproducible, and selective analysis of risperidone. The method was successfully used for estimation of the equilibrium solubility of risperidone, and for quantification of risperidone as the bulk drug in a commercially available preparation, in in-house-developed mucoadhesive microemulsion formulations, and in solution.