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Two-dimensional Model of Fluid Flow and Distribution of Nutrient Concentration in a Microfluidic Device

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Języki publikacji
EN
Abstrakty
EN
During the past few years, the process of miniaturisation in the field of biochemical laboratory equipment led to the introduction of the so-called "lab-on-a-chip" microdevices, which combine separate functional units into a complex, multifunctional apparatus. Fluid dynamics plays an essential role in the development of such equipment, since frequently the major part of chemical analysis is based on soluble analytes. In this work, we consider a device for the analysis of cell growth under different conditions. In this device, dozens of cell spots absorb the nutrient (analyte) from the liquid medium. The concentration of the analyte must be strictly controlled to maintain a specific microenvironment. A two-dimensional model for the flow field and the distribution of concentration of the analyte is developed taking into account the geometrical shape of the spot with a simplified absorption model. The dependence of the results on the controlling parameters is investigated in order to determine the influence of the presence of the cell spot on the distribution of the analyte.
Rocznik
Strony
135--155
Opis fizyczny
Bibliogr. 11 poz., rys.
Twórcy
Bibliografia
  • [1] Chung B G, Flanagan L A, Rhee S W, Schwartz P H, Lee A P, Monuki E S and Jeon N L 2005 Lab on a Chip 5 (4) 401
  • [2] Kim L, Toh Y C, Yoldman J and Yu H 2007 Lab on a Chip 7 681
  • [3] Reyes D R, D. Iossifidis, Auroux P A and Manz A 2002 Analytical Chemistry 74 (12) 2623
  • [4] Auroux P A, lossifidis D, Reyes D R and Manz A 2002 Analytical Chemistry 74 (12) 2636
  • [5] Repetto R, Malvin T, Brooks S, Jones M, Friedrich D. King J, Waters S, Gratton M, Oliver J and Witelski T 2007 Bio-opto-micro-fluidic Devices for Celi Interrogations, 7th Mathematics in Medicine Study Group, University of Southampton
  • [6] Taylor G 1957 Dispersion of Soluble. Matter in Solnent Flowing Slowly through a Tube, Proc. Royal Society of London, Scries A, Mathematical and Physical Sciences
  • [7] Minkowycz W J, Sparrow E M, Schneider G E and Pletchcr R H 1988 Handbook of Numerical Heat Transfer, Wiley
  • [8] Mikielewicz D 2007 Computer Methods in Heat Transfer, Lecture Notes, Gdańsk University of Technology (in Polish)
  • [9] Kraus T, Yerpoorte E, Linder V, Franks W, Hierlemann A, Heer F, Hafizovic S. Fujii T, Rooija N F de and Koster S 2006 Lab on a Chip 6 218
  • [10] Bruus H 2008 Theoretical Microfluidics, Oxford University Press
  • [11] Walker G M. Zeringueb H C and Beebe D J 2004 Lab on a Chip 4 91
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPG8-0067-0024
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