(-)-Menthol-β-cyclodextrin inclusion complex production and characterization

• Autorzy: Zhu Guangyong , Xiao Zuobing , Zhou Rujun , Liu Junhua , Zhu Guangxu , Zheng Xiongjian

Identyfikatory

DOI

10.2478/pjct-2022-0008

• Języki publikacji: EN

Abstrakty

EN

(-)-Menthol has been widely used in clinical medicine, flavor, and fragrance. However, high volatility, short retention time, low solubility in water, and whisker growth of menthol are crucial problems for its application. In this paper, (-)-menthol-β-cyclodextrin inclusion complex was fabricated to solve these problems. The product was characterized by X-ray diffraction, Fourier transform infrared spectroscopy and thermogravimetric analysis. The results showed that menthol was successfully encapsulated in the cavity of β-cyclodextrin. Menthol itself vaporized almost completely at around 120^oC, while the maximum menthol release rate occurred at 267.5^o C after the formation of the inclusion complex. The stability and retention time were improved. The menthol release reaction order, apparent activation energy and the pre-exponential factor were obtained and their values were 0, 142.9 kJ/mol and 1.6 × 10¹³ respectively. The structure of menthol-β-cyclodextrin inclusion complex was investigated by molecular simulation and the minimum energy, –116.7 kJ/mol, was obtained at –0.8 × 10^–10 m.

Słowa kluczowe

EN

Menthol-β-cyclodextrin inclusion complex; Preparation; Characterization; Kinetics; Molecular mechanics

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2022
• Tom: Vol. 24, nr 2
• Strony: 1--7
• Opis fizyczny: Bibliogr. 32 poz., rys., tab., wz.

Twórcy

autor

Zhu Guangyong

• Shanghai Institute of Technology China

autor

Xiao Zuobing

• Shanghai Institute of Technology China
• Shanghai Jiao Tong University, China

autor

Zhou Rujun

• Shanghai Institute of Technology China

autor

Liu Junhua

• Shanghai Institute of Technology China

autor

Zhu Guangxu

• Canada

autor

Zheng Xiongjian

• ShangHai LanHic Biotech Co., Ltd. China

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).