Computational studies of the mitochondrial carrier family SLC25. Present status and future perspectives

• Autorzy: Pasquadibisceglie Andrea , Polticelli Fabio

Identyfikatory

DOI

10.1515/bams-2021-0018

• Języki publikacji: EN

Abstrakty

EN

The members of the mitochondrial carrier family, also known as solute carrier family 25 (SLC25), are transmembrane proteins involved in the translocation of a plethora of small molecules between the mitochondrial intermembrane space and the matrix. These transporters are characterized by three homologous domains structure and a transport mechanism that involves the transition between different conformations. Mutations in regions critical for these transporters’ function often cause several diseases, given the crucial role of these proteins in the mitochondrial homeostasis. Experimental studies can be problematic in the case of membrane proteins, in particular concerning the characterization of the structure–function relationships. For this reason, computational methods are often applied in order to develop new hypotheses or to support/explain experimental evidence. Here the computational analyses carried out on the SLC25 members are reviewed, describing the main techniques used and the outcome in terms of improved knowledge of the transport mechanism. Potential future applications on this protein family of more recent and advanced in silico methods are also suggested.

Słowa kluczowe

EN

membrane proteins; mitochondrial carrier family; molecular dynamics; protein structure modelling; solute carrier family 25

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2021
• Tom: Vol. 17, no. 2
• Strony: 65--78
• Opis fizyczny: Bibliogr. 177 poz., rys., tab.

Twórcy

autor

Pasquadibisceglie Andrea

• Department of Sciences, Roma Tre University, Rome, Italy

autor

Polticelli Fabio

• Department of Sciences, Roma Tre University, Viale Guglielmo Marconi 446, 00146 Rome, Italy
• National Institute of Nuclear Physics, Roma Tre Section, Rome, Italy, Phone: [phone], Fax: [phone]

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).