Application of divergence entropy to characterize the structure of lipid-binding proteins

• Autorzy: Rosicka R. , Banach M. , Roterman-Konieczna I.

Identyfikatory

DOI

10.1515/bams-2015-0017

• Języki publikacji: EN

Abstrakty

EN

The lipid-binding protein present in the human brain is the object of this analysis. The expression of these proteins is especially important for nervous cell differentiation and their migration in the process of the development of the brain. The “fuzzy oil drop” model applied to the analysis of these proteins may suggest the mechanism of complex generation. It is shown that this type of complex may appear spontaneously in water environment. The presence of ligand does not imply any form of adaptation of the polypeptide chain to the ligand molecule. It can be speculated that ligand binding is of a static character without the necessity for mutual structural fitting. The structures of polypeptide in the apo- and complexed forms do not differ in respect to hydrophobic core formation. Such an interpretation is different than that observed in other ligand-binding proteins where the binding cavity needs to be specially fitted to the specific ligand. It can also be concluded that the lipid-binding process is of low specificity in this case.

Słowa kluczowe

EN

human brain; hydrophobicity; lipid binding; protein structure

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; De Gruyter
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2015
• Tom: Vol. 11, no. 3
• Strony: 171--176
• Opis fizyczny: Bibliogr. 18 poz., rys., wykr.

Twórcy

autor

Rosicka R.

• Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Krakow, Poland
• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland

autor

Banach M.

• Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Krakow, Poland
• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland

autor

Roterman-Konieczna I.

• Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, 31-530 Krakow, Łazarza 16, Poland

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