The role of the spatially fractionated radiation therapy in the management of advanced bulky tumors

Mahmoudi, Farshid; Shahbazi-Gahrouei, Daryoush; Chegeni, Nahid

doi:10.2478/pjmpe-2021-0015

Artykuł - szczegóły

Tytuł artykułu

The role of the spatially fractionated radiation therapy in the management of advanced bulky tumors

Autorzy

Mahmoudi Farshid , Shahbazi-Gahrouei Daryoush , Chegeni Nahid

Wybrane pełne teksty z tego czasopisma

http://content.sciendo.com/view/journals/pjmpe/pjmpe-overview.xml

Identyfikatory

DOI

10.2478/pjmpe-2021-0015

Warianty tytułu

Języki publikacji

Abstrakty

Spatially fractionated radiation therapy (SFRT) refers to the delivery of a single large dose of radiation within the target volume in a heterogeneous pattern using either a custom GRID block, multileaf collimators, and virtual methods such as helical tomotherapy or synchrotron-based microbeams. The potential impact of this technique on the regression of bulky deep-seated tumors that do not respond well to conventional radiotherapy has been remarkable. To date, a large number of patients have been treated using the SFRT techniques. However, there are yet many technical and medical challenges that have limited their routine use to a handful of clinics, most commonly for palliative intent. There is also a poor understanding of the biological mechanisms underlying the clinical efficacy of this approach. In this article, the methods of SFRT delivery together with its potential biological mechanisms are presented. Furthermore, technical challenges and clinical achievements along with the radiobiological models used to evaluate the efficacy and safety of SFRT are highlighted.

Słowa kluczowe

spatially fractionated radiation therapy SFRT GRID therapy bystander effect radiotherapy bulky tumor

Wydawca

Polskie Towarzystwo Fizyki Medycznej
De Gruyter

Czasopismo

Polish Journal of Medical Physics and Engineering

Rocznik

2021

Tom

Vol. 27, Iss. 2

Strony

123--135

Opis fizyczny

Bibliogr. 75 poz., rys., tab.

Twórcy

autor

Mahmoudi Farshid

Dept. of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

autor

Shahbazi-Gahrouei Daryoush

shahbazi24@yahoo.com

Dept. of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

autor

Chegeni Nahid

Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Bibliografia

1. Tao L, Rakfal S, Wu A. Comparison of integral doses in conventional 2D, conformal 3D and IMRT plans. Medical Physics. 2002;29(6):1211.
2. Arabpour A, Shahbazi-Gahrouei D. Effect of Hypofractionation on Prostate Cancer Radiotherapy. International Journal of Cancer Management. 2017;10(10):e12204. https://doi.org/10.5812/ijcm.12204
3. Shahbazi-Gahrouei D, Gookizadeh A, Sohrabi M, Arab Z. Normal tissues absorbed dose and associated risk in breast radiotherapy. Journal of Radiobiology. 2015;2(1).
4. Peñagarícano JA, Moros EG, Ratanatharathorn V, Yan Y, Corry P. Evaluation of spatially fractionated radiotherapy (GRID) and definitive chemoradiotherapy with curative intent for locally advanced squamous cell carcinoma of the head and neck: initial response rates and toxicity. Int J Radiat Oncol Biol Phys. 2010;76(5):1369-1375. https://doi.org/10.1016/j.ijrobp.2009.03.030
5. Kaiser A, Mohiuddin MM, Jackson GL. Dramatic response from neoadjuvant, spatially fractionated GRID radiotherapy (SFGRT) for large, high-grade extremity sarcoma. Journal of Radiation Oncology. 2013;2(1):103-106. https://doi.org/10.1007/s13566-012-0064-5
6. Asur R, Butterworth KT, Penagaricano JA, Prise KM, Griffin RJ. High dose bystander effects in spatially fractionated radiation therapy. Cancer Letters. 2015;356(1):52-57. https://doi.org/10.1016/j.canlet.2013.10.032
7. Mohiuddin M, Fujita M, Regine WF, Megooni AS, Ibbott GS, Ahmed MM. High-dose spatially-fractionated radiation (GRID): a new paradigm in the management of advanced cancers. Int J Radiat Oncol Biol Phys. 1999;45(3):721-727. https://doi.org/10.1016/S0360-3016(99)00170-4
8. Saeb M, Shahbazi-Gahrouei D, Monadi S. Evaluation of targeted image-guided radiation therapy treatment planning system by use of american association of physicists in medicine task group-119 test cases. Journal of Medical Signals and Sensors. 2018;8(2):95. https://doi.org/10.4103/jmss.JMSS_44_17
9. Mohiuddin M, Curtis DL, Grizos WT, Komarnicky L. Palliative treatment of advanced cancer using multiple nonconfluent pencil beam radiation: A pilot study. Cancer. 1990;66(1):114-118. https://doi.org/10.1002/1097-0142(19900701)66:1<114::AIDCNCR2820660121>3.0.CO;2-L
10. Mohiuddin M, Stevens JH, Reiff JE, Huq MS, Suntharalingam N. Spatially fractionated (GRID) radiation for palliative treatment of advanced cancer. Radiation Oncology Investigations. 1996;4(1):41-47. https://doi.org/10.1002/(SICI)1520-6823(1996)4:1<41::AIDROI7>3.0.CO;2-M
11. Mohiuddin M, Kudrimoti M, Regine W, Meigooni A, Zwicker R. Spatially fractionated radiation (SFR) in the management of advanced cancer. Int J Radiat Oncol Biol Phys. 2002;54:342-343. https://doi.org/10.1016/S0360-3016(02)03646-5
12. Meigooni A, Malik U, Zhang H, et al. Grid: A location dependent intensity modulated radiotherapy for bulky tumors. Iranian Journal of Radiation Research (Print). 2005;2(4):167-174.
13. Zwicker RD, Meigooni A, Mohiuddin M. Therapeutic advantage of grid irradiation for large single fractions. Int J Radiat Oncol Biol Phys. 2004;58(4):1309-1315. https://doi.org/10.1016/j.ijrobp.2003.07.003
14. Buckey C, Stathakis S, Cashon K, et al. Evaluation of a commercially-available block for spatially fractionated radiation therapy. Journal of Applied Clinical Medical Physics. 2010;11(3). https://doi.org/10.1120/jacmp.v11i3.3163
15. Ha JK, Zhang G, Naqvi SA, Regine WF, Cedric XY. Feasibility of delivering grid therapy using a multileaf collimator. Medical Physics. 2006;33(1):76-82. https://doi.org/10.1118/1.2140116
16. Neuner G, Mohiuddin MM, Vander Walde N, et al. High-dose spatially fractionated GRID radiation therapy (SFGRT): a comparison of treatment outcomes with Cerrobend vs. MLC SFGRT. Int J Radiat Oncol Biol Phys. 2012;82(5):1642-1649. https://doi.org/10.1016/j.ijrobp.2011.01.065
17. Cole AJ, McGarry CK, Butterworth KT, et al. Investigating the influence of respiratory motion on the radiation induced bystander effect in modulated radiotherapy. Physics in Medicine & Biology. 2013;58(23):8311. https://doi.org/10.1088/0031-9155/58/23/8311
18. Jordan K, Francis W, Dar A, Yu E, Yartsev S, Chen J. SU‐C‐BRA‐01: Efficient Generation of Beamlet Arrays with Hybrid Multileaf Collimator for Grid Therapy. Medical Physics. 2011;38(6Part2):3368-3368. https://doi.org/10.1118/1.3611461
19. Almendral P, Mancha PJ, Roberto D. Feasibility of a simple method of hybrid collimation for megavoltage grid therapy. Medical Physics. 2013;40(5):051712. https://doi.org/10.1118/1.4801902
20. Zhang X, Penagaricano J, Yan Y, et al. Spatially fractionated radiotherapy (GRID) using helical tomotherapy. Journal of Applied Clinical Medical Physics. 2016;17(1). https://doi.org/10.1120/jacmp.v17i1.5934
21. Zhang X, Penagaricano J, Yan Y, et al. Application of spatially fractionated radiation (GRID) to helical tomotherapy using a novel TOMOGRID template. Technology in Cancer Research & Treatment. 2016;15(1):91-100. https://doi.org/10.7785/tcrtexpress.2013.600261
22. Narayanasamy G, Zhang X, Meigooni A, et al. Therapeutic benefits in grid irradiation on Tomotherapy for bulky, radiation-resistant tumors. Acta Oncologica. 2017;56(8):1043-1047. https://doi.org/10.1080/0284186X.2017.1299219
23. Wu X, Wright J, Gupta S, Pollack A. On modern technical approaches of three-dimensional high-dose lattice radiotherapy (LRT). Cureus. 2010;2(3). https://doi.org/10.7759/cureus.9
24. Amendola BE, Perez N, Wu X, et al. Lattice radiotherapy with rapidarc for treatment of gynecological tumors: dosimetric and early clinical evaluations. Cureus. 2010;2(9). https://doi.org/10.7759/cureus.15
25. Amendola BE, Perez NC, Wu X, Suarez JMB, Lu JJ, Amendola M. Improved outcome of treating locally advanced lung cancer with the use of Lattice Radiotherapy (LRT): A case report. Clinical and Translational Radiation Oncology. 2018;9:68-71. https://doi.org/10.1016/j.ctro.2018.01.003
26. Jin J-Y, Zhao B, Kaminski JM, et al. A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique. Radiotherapy and Oncology. 2015;117(3):483-486. https://doi.org/10.1016/j.radonc.2015.07.047
27. Schültke E, Balosso J, Breslin T, et al. Microbeam radiation therapy-grid therapy and beyond: a clinical perspective. The British Journal of Radiology. 2017;90(1078):20170073. https://doi.org/10.1259/bjr.20170073
28. Slatkin DN, Spanne P, Dilmanian F, Sandborg M. Microbeam radiation therapy. Medical Physics. 1992;19(6):1395-1400. https://doi.org/10.1118/1.596771
29. Grotzer M, Schültke E, Bräuer-Krisch E, Laissue J. Microbeam radiation therapy: clinical perspectives. Physica Medica. 2015;31(6):564-567. https://doi.org/10.1016/j.ejmp.2015.02.011
30. Slatkin D, Spanne P, Dilmanian F, Gebbers J, Laissue J. Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler. Proceedings of the National Academy of Sciences. 1995;92(19):8783-8787. https://doi.org/10.1073/pnas.92.19.8783
31. Keivan H, Shahbazi-Gahrouei D, Shanei A, Amouheidari A. Assessment of imprecise small photon beam modeling by two treatment planning system Algorithms. Journal of Medical Signals and Sensors. 2018;8(1):39. https://doi.org/10.4103/jmss.JMSS_28_17
32. Keivan H, Shahbazi-Gahrouei D, Shanei A. Evaluation of dosimetric characteristics of diodes and ionization chambers in small megavoltage photon field dosimetry. International Journal of Radiation Research. 2018;16(3):311-321.
33. Wu X, Ahmed M, Pollack A. On modern technical approaches of 3D high-dose lattice radiotherapy (LRT). Int J Radiat Oncol Biol Phys. 2009;75(3):S723. https://doi.org/10.1016/j.ijrobp.2009.07.1647
34. Nobah A, Mohiuddin M, Devic S, Moftah B. Effective spatially fractionated GRID radiation treatment planning for a passive grid block. The British Journal of Radiology. 2015;88(1045):20140363. https://doi.org/10.1259/bjr.20140363
35. Costlow HN, Zhang H, Das IJ. A treatment planning approach to spatially fractionated megavoltage grid therapy for bulky lung cancer. Medical Dosimetry. 2014;39(3):218-226. https://doi.org/10.1016/j.meddos.2014.02.004
36. Chegeni N, Karimi AH, Jabbari I, Arvandi S. Photoneutron dose estimation in GRID therapy using an anthropomorphic phantom: A monte carlo study. Journal of Medical Signals and Sensors. 2018;8(3):175. https://doi.org/10.4103/jmss.JMSS_13_18
37. Wang X, Charlton MA, Esquivel C, Eng TY, Li Y, Papanikolaou N. Measurement of neutron dose equivalent outside and inside of the treatment vault of GRID therapy. Medical Physics. 2013;40(9):093901. https://doi.org/10.1118/1.4816653
38. Karimi AH, Brkić H, Shahbazi-Gahrouei D, Haghighi SB, Jabbari I. Essential considerations for accurate evaluation of photoneutron contamination in Radiotherapy. Applied Radiation and Isotopes. 2019;145:24-31. https://doi.org/10.1016/j.apradiso.2018.12.007
39. Khosravi M, Shahbazi-Gahrouei D, Jabbari K, et al. Photoneutron contamination from an 18 MV Saturne medical linear accelerator in the treatment room. Radiation Protection Dosimetry. 2013;156(3):356-363. https://doi.org/10.1093/rpd/nct078
40. Tajiki S, Gholami S, Esfahani M, et al. Photon and photon-neutron experimental dosimetry in Grid therapy with 18 MV photon beams. Journal of Radiotherapy in Practice.1-7. https://doi.org/10.1017/S1460396920000655
41. Hopewell JW, Trott K-R. Volume effects in radiobiology as applied to radiotherapy. Radiotherapy and Oncology. 2000;56(3):283-288. https://doi.org/10.1016/S0167-8140(00)00236-X
42. Marks H. Clinical experience with irradiation through a GRID. Radiology. 1952;58(3):338-342. https://doi.org/10.1148/58.3.338
43. Reiff JE, Huq MS, Mohiuddin M, Suntharalingam N. Dosimetric properties of megavoltage grid therapy. Int J Radiat Oncol Biol Phys. 1995;33(4):937-942. https://doi.org/10.1016/0360-3016(95)00114-3
44. Huhn JL, Regine WF, Valentino JP, Meigooni AS, Kudrimoti M, Mohiuddin M. Spatially fractionated GRID radiation treatment of advanced neck disease associated with head and neck cancer. Technology in Cancer Research & Treatment. 2006;5(6):607-612. https://doi.org/10.1177/153303460600500608
45. Asur RS, Sharma S, Chang C-W, et al. Spatially fractionated radiation induces cytotoxicity and changes in gene expression in bystander and radiation adjacent murine carcinoma cells. Radiation Research. 2012;177(6):751-765. https://doi.org/10.1667/RR2780.1
46. Mothersill C, Rusin A, Fernandez-Palomo C, Seymour C. History of bystander effects research 1905-present; what is in a name? International Journal of Radiation Biology. 2018;94(8):696-707. https://doi.org/10.1080/09553002.2017.1398436
47. Sathishkumar S, Dey S, Meigooni AS, et al. The impact of TNF-α induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiation. Technology in Cancer Research & Treatment. 2002;1(2):141-147. https://doi.org/10.1177/153303460200100207
48. Desai S, Kobayashi A, Konishi T, Oikawa M, Pandey BN. Damaging and protective bystander cross-talk between human lung cancer and normal cells after proton microbeam irradiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2014;763:39-44. https://doi.org/10.1016/j.mrfmmm.2014.03.004
49. Sathishkumar S, Boyanovski B, Karakashian A, et al. Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosis. Cancer Biology & Therapy. 2005;4(9):979-986. https://doi.org/10.4161/cbt.4.9.1915
50. Kanagavelu S, Gupta S, Wu X, et al. In vivo effects of lattice radiation therapy on local and distant lung cancer: potential role of immunomodulation. Radiat Res. 2014;182(2):149-162. https://doi.org/10.1667/RR3819.1
51. Manda K, Glasow A, Paape D, Hildebrandt G. Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells. Frontiers in Oncology. 2012;2:102. https://doi.org/10.3389/fonc.2012.00102
52. Lugade AA, Moran JP, Gerber SA, Rose RC, Frelinger JG, Lord EM. Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. The Journal of Immunology. 2005;174(12):7516-7523. https://doi.org/10.4049/jimmunol.174.12.7516
53. Lee Y, Auh SL, Wang Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood. 2009;114(3):589-595. https://doi.org/10.1182/blood-2009-02-206870
54. Edwards J, Shah P, Huhn J, et al. Definitive GRID and fractionated radiation in bulky head and neck cancer associated with low rates of distant metastasis. Int J Radiat Oncol Biol Phys. 2015;93(3):E334. https://doi.org/10.1016/j.ijrobp.2015.07.1399
55. Gupta S, Zagurovskaya M, Wu X, Sathishkumar S, Awan S, Mohiuddin M. Spatially Fractionated Grid High-dose radiation-induced tumor regression in A549 lung adenocarcinoma xenografts: cytokines and ceramide regulators balance in abscopal phenomena. Sylvester Comprehensive Cancer Center. 2014;20.
56. Griffin RJ, Koonce NA, Dings RPM, et al. Microbeam radiation therapy alters vascular architecture and tumor oxygenation and is enhanced by a galectin-1 targeted anti-angiogenic peptide. Radiation Research. 2012;177(6):804-812. https://doi.org/10.1667/RR2784.1
57. Peters ME, Shareef MM, Gupta S, et al. Potential utilization of bystander/abscopal-mediated signal transduction events in the treatment of solid tumors. Current Signal Transduction Therapy. 2007;2(2):129-143. https://doi.org/10.2174/157436207780619509
58. Billena C, Khan AJ. A current review of spatial fractionation: back to the future? Int J Radiat Oncol Biol Phys. 2019;104(1):177-187. https://doi.org/10.1016/j.ijrobp.2019.01.073
59. Kudrimoti M, Mohiuddin M, Ahmed M, et al. Use of high dose spatially fractionated radiation (GRID therapy) in management of large, poor prognostic stage III (> 10cms) soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2004;60(1):S575. https://doi.org/10.1016/j.ijrobp.2004.07.564
60. Somaiah N, Warrington J, Taylor H, Ahmad R, Tait D, Glees J. High dose spatially fractionated radiotherapy (SFR) using a megavoltage GRID in advanced lung tumors: Preliminary experience in UK. Int J Radiat Oncol Biol Phys. 2008;72(1):S490. https://doi.org/10.1016/j.ijrobp.2008.06.1439
61. Suarez JMB, Amendola BE, Perez N, Amendola M, Wu X. The use of lattice radiation therapy (LRT) in the treatment of bulky tumors: a case report of a large metastatic mixed Mullerian ovarian tumor. Cureus. 2015;7(11).
62. Amendola BE, Perez NC, Wu X, Amendola MA, Qureshi IZ. Safety and efficacy of lattice radiotherapy in voluminous non-small cell lung cancer. Cureus. 2019;11(3). https://doi.org/10.7759/cureus.4263
63. Choi JI, Daniels J, Cohen D, Li Y, Ha CS, Eng TY. Clinical Outcomes of Spatially Fractionated GRID Radiotherapy in the Treatment of Bulky Tumors of the Head and Neck. Cureus. 2019;11(5). https://doi.org/10.7759/cureus.4637
64. Niemierko A. Reporting and analyzing dose distributions: a concept of equivalent uniform dose. Medical Physics. 1997;24(1):103-110. https://doi.org/10.1118/1.598063
65. Gholami S, Nedaie HA, Longo F, Ay MR, Wright S, Meigooni AS. Is grid therapy useful for all tumors and every grid block design? Journal of Applied Clinical Medical Physics. 2016;17(2). https://doi.org/10.1120/jacmp.v17i2.6015
66. Zhang H, Zhong H, Barth RF, Cao M, Das IJ. Impact of dose size in single fraction spatially fractionated (grid) radiotherapy for melanoma. Medical physics. 2014;41(2):021727. https://doi.org/10.1118/1.4862837
67. Naqvi SA, Mohiuddin MM, Ha JK, Regine WF. Effects of tumor motion in GRID therapy. Medical physics. 2008;35(10):4435-4442. https://doi.org/10.1118/1.2977538
68. Guerrero M, Li XA. Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy. Physics in Medicine & Biology. 2004;49(20):4825. https://doi.org/10.1088/0031-9155/49/20/012
69. Ekstrand KE. The Hug-Kellerer equation as the universal cell survival curve. Physics in Medicine & Biology. 2010;55(10):N267. https://doi.org/10.1088/0031-9155/55/10/N01
70. Suchowerska N, Ebert MA, Zhang M, Jackson M. In vitro response of tumour cells to non-uniform irradiation. Physics in Medicine & Biology. 2005;50(13):3041. https://doi.org/10.1088/0031-9155/50/13/005
71. Butterworth KT, McGarry CK, Trainor C, O'Sullivan JM, Hounsell AR, Prise KM. Out-of-field cell survival following exposure to intensity-modulated radiation fields. Int J Radiat Oncol Biol Phys. 2011;79(5):1516-1522. https://doi.org/10.1016/j.ijrobp.2010.11.034
72. Butterworth KT, McGarry CK, Trainor C, et al. Dose, dose-rate and field size effects on cell survival following exposure to nonuniform radiation fields. Physics in Medicine & Biology. 2012;57(10):3197. https://doi.org/10.1088/0031-9155/57/10/3197
73. Peng V, Suchowerska N, Rogers L, Claridge Mackonis E, Oakes S, McKenzie DR. Grid therapy using high definition multileaf collimators: realizing benefits of the bystander effect. Acta Oncologica. 2017;56(8):1048-1059. https://doi.org/10.1080/0284186X.2017.1299939
74. McMahon SJ, Butterworth KT, Trainor C, et al. A kinetic-based model of radiation-induced intercellular signalling. PloS one. 2013;8(1):e54526. https://doi.org/10.1371/journal.pone.0054526
75. Butterworth KT, Ghita M, McMahon SJ, et al. Modelling responses to spatially fractionated radiation fields using preclinical imageguided radiotherapy. The British Journal of Radiology. 2017;90(1069):20160485. https://doi.org/10.1259/bjr.20160485

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Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).

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