The promise of composite polymers for bone tissue engineering

• Autorzy: Amedee J.
• Konferencja: Biomaterials in medicine and veterinary medicine : 25th anniversary conference : 13-16 October 2016, Rytro, Poland
• Języki publikacji: EN

Abstrakty

EN

The repair of bone defects is of particular interest for orthopaedic, oral, maxillofacial, and dental surgery. Bone loss is conventionally reconstructed by bone grafting. Depending on size and location of the defect, this method has limits and risks. In addition, in the context of reconstruction of the craniofacial skeleton after radiation therapy, we need to improve therapeutic options for patients suffering from such disastrous sequelae of radiation therapy. While the use of BMPs has been approved for bone regeneration applications, their use is contraindicated in a carcinological context, due to concerns that these anabolic growth factors may contribute to tumor cell proliferation. Moreover, the main limitations are to regenerate a functional vasculature [1] and to restore bone innervation that also played a major role for bone tissue regeneration [2,3]. In such context, biomaterials such as calcium phosphate matrices, free of reparative cells, cannot offer sufficient potential for supporting especially vascularization of newly formed bone. Polymers and mainly composite based-polysaccharides, because of their versatility, their possible supplementation with a mineral phase (i.e hydroxyapatite particles), have immense potential for mimicking bone tissue, by trapping osteogenic and angiogenic factors and then promoting both osteogenesis and angiogenesis [4,5]. The other challenge in the field of bone tissue engineering is to favour anchorage of sensory neurons within 3D matrices that could produce neurotrophic factors [6], activate the coupling of osteogenesis and angiogenesis. Here, we will describe a cell-free approach for bone tissue engineering [7] using injectable composite polymers, their in vitro and in vivo validation in preclinical models from small to large animals. We will also show how composite polymer chemistry can also favour cell interactions between mesenchymal stem cells, endothelial cells and stimulate bone tissue regeneration.

Słowa kluczowe

EN

polymers; bone tissue engineering; composite

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2016
• Tom: Vol. 19, no. 138 spec. iss.
• Strony: 7
• Opis fizyczny: Bibliogr. 7 poz.

Twórcy

autor

Amedee J.

• Inserm U1026 Tissue Bioengineering University of Bordeaux, Bordeaux, France

Bibliografia

• [1] Barabaschi GD, Manoharan V, Li Q, Bertassoni LE. Engineering Pre-vascularized Scaffolds for Bone Regeneration. Adv Exp Med Biol. 2015;881:79-94
• [2] Li J, Ahmad T, Spetea M, Ahmed M, Kreicbergs A. Bone reinnervation after fracture: a study in the rat. J Bone Miner Res. 2001;16:1505-10
• [3] Song D, Jiang X, Zhu S, Li W, Khadka A, Hu J. Denervation impairs bone regeneration during distraction osteogenesis in rabbit tibia lengthening. Acta orthopaedica. 2012;83:406-10
• [4] Fricain JC, Schlaubitz S, Le Visage C, Arnault I, Derkaoui SM, Siadous R, et al. A nano-hydroxyapatite— pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering. Biomaterials. 2013;34:2947-59
• [5] Guerrero J, Catros S, Derkaoui SM, Lalande C, Siadous R, Bareille R, et al. Cell interactions between human progenitor-derived endothelial cells and human mesenchymal stem cells in a three-dimensional macroporous polysaccharide-based scaffold promote osteogenesis. Acta biomater. 2013;9:8200-13.
• [6] Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, et al. Sema3A regulates bone-mass accrual through sensory innervations. Nature. 2013;497:490-3.
• [7] Bueno EM et al. Cell-free and cell-based approaches for bone regeneration. Nat Rev Rheumatol 2009; 5: 685- 697.

Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).