Hippocampus, spare or not to spare? Normal Tissue Complication Probability considerations

• Autorzy: Mężeński Piotr

Identyfikatory

DOI

10.2478/pjmpe-2024-0022

• Języki publikacji: EN

Abstrakty

EN

Purpose: The purpose of the study was to use the Lyman-Kutcher-Burman model to calculate and compare neurocognitive function (NCF) impairment in the two types of dose distributions in Volumetric Arc Whole-brain radiotherapy (VMAT WBRT). Methods: The total dose prescribed to the Planning Target Volume (PTV) was 25 Gy and 30 Gy in 10 fractions. During the optimization of the Volumetric Arc Therapy Hippocampal-Avoidant WBRT (VMAT HA-WBRT) plan, the left and right hippocampus the D₁₀₀ < 9 Gy, and the point dose D_max < 16 Gy were minimalized based on RTOG0933 criteria. As an alternative 59 plans for non-hippocampus sparing, 25 Gy, and 59 plans for 30 Gy VMAT WBRT plans were prepared. To calculate the probability of NCF impairment, the Lyman-Kutcher-Burman (LKB) normal tissue complication probability model was used. Results: The probability of NCF impairment in the HA-WBRT VMAT was equal to 38%, and it was significantly lower compared to 90% in the 25 Gy WBRT VMAT and 97% in the 30 Gy WBRT VMAT (p < 0.05). Conclusions: The probability of NCF impairment was 51-59 percentage points lower in VMAT HA-WBRT compared to VMAT WBRT plans. To achieve a 5% probability of NCF impairment, the D40 value should be reduced to a value of approximately 1 Gy. However, due to the complicated nature and types of NFC impairment, further analysis and strategies are needed to optimize dose distribution.

Słowa kluczowe

EN

hippocampus; NTCP; NCF impairment

• Wydawca: Polskie Towarzystwo Fizyki Medycznej
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2024
• Tom: Vol. 30, Iss. 4
• Strony: 182--188
• Opis fizyczny: Bibliogr. 26 poz., rys., tab.

Twórcy

autor

Mężeński Piotr

• Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025).