An HPLC method for the determination of the anticancer complex 3-hydroxycarboplatin

• Autorzy: Yang Sh. , Chen X. , Zhen P , Ye Q. , Xie X , Liu W.
• Języki publikacji: EN

Abstrakty

EN

A simple and rapid HPLC method using a photodiode array (PDA) detector for the analysis of 3-hydroxycarboplatin and its related complex has been established for the first time. Separation of 3-hydroxycarboplatin and 3-hydroxy-1,1-cyclobutanedicarboxylic acid (3-HO-cbdca) was carried out on a Phenomenex ODS3 column using an aqueous solution containing 50 mM ammonium acetate and 5 mM sodium 1-octanesulfonate as the mobile phase. The flow rate was 0.8 mL min^-1, the column temperature was 40°C, and the detection wavelength was 230 nm for 3-hydroxycarboplatin and 220 nm for 3-HO-cbdca. Different analytical performance parameters such as precision, accuracy, linearity, stability of the solution, specificity, limit of detection (LOD), limit of quantification (LOQ), and system suitability were determined using the Empower 2 software. The calibration curve of standard 3-hydroxycarboplatin showed good linearity (r = 0.9995) within the range 0.5–1.4 mg mL^-1. The method was accurate and precise, with an average accuracy of 100.4% (RSD = 1.53%, n = 9), and the results of the system suitability test showed symmetrical peaks, good resolution (Rs), and repeatability. It can be applied to the quality control of 3-hydroxycarboplatin.

Słowa kluczowe

EN

anticancer complex; 3-hydroxycarboplatin; HPLC method

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2011
• Tom: Vol. 23, no. 4
• Strony: 539--550
• Opis fizyczny: Bibliogr. 18 poz., rys., tab.

Twórcy

autor

Yang Sh.

• Kunming Institute of Precious Metals State Key Lab of Advanced Technology for Platinum Metals Kunming 650106 China
• Yunnan Normal University School of Chemistry and Chemical Engineering Kunming 650092 China

autor

Chen X.

• Kunming Institute of Precious Metals State Key Lab of Advanced Technology for Platinum Metals Kunming 650106 China

autor

Zhen P

• Yunnan Normal University School of Chemistry and Chemical Engineering Kunming 650092 China

autor

Ye Q.

• Kunming Institute of Precious Metals State Key Lab of Advanced Technology for Platinum Metals Kunming 650106 China

autor

Xie X

• Yunnan Normal University School of Chemistry and Chemical Engineering Kunming 650092 China

autor

Liu W.

• Kunming Institute of Precious Metals State Key Lab of Advanced Technology for Platinum Metals Kunming 650106 China

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