Attempt at a systemic outlook on aging and carcinogenesis

Piwowar, M.; Dygut, J.; Piwowar, P.; Konieczny, L.; Roterman, I.

doi:10.1515/bams-2014-0012

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Tytuł artykułu

Attempt at a systemic outlook on aging and carcinogenesis

Autorzy

Piwowar M. , Dygut J. , Piwowar P. , Konieczny L. , Roterman I.

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.1515/bams-2014-0012

Warianty tytułu

Języki publikacji

Abstrakty

Two of the key problems plaguing humanity – aging and carcinogenesis – are inexorably linked. While their nature seems different, their mechanisms have a lot in common. Evidence suggests that aging is the result of spontaneous synthesis and accumulation of improperly folded proteins in cells, leading to a variety of pathologies. As for carcinogenesis, it is tied to genetic mutations – permanent, covalent changes in the DNA. Both processes are random in character; however, unlike mutations, the accumulation of malformed proteins is not genetically determined. Instead, control over this process hinges upon regulating the protein exchange rate – a phenomenon that seems a likely candidate for the basic aging control mechanism. Although mutations themselves may be counteracted in a controlled manner, their effects typically cannot. The mechanisms of aging and carcinogenesis, while functionally different, remain correlated: an aging cell is rendered more susceptible to mutational changes. The rapidly growing body of information regarding aging and carcinogenesis enables a systemic approach to both these phenomena – an approach that is attempted in this review.

Słowa kluczowe

aging Congo red creation of organisms eukaryotic cells advent evolutionary time functionrelated mutations partly unfolded proteins systems biology tumorigenesis

Wydawca

Uniwersytet Jagielloński - Collegium Medicum
Index Copernicus Sp. z o.o.

Czasopismo

Bio-Algorithms and Med-Systems

Rocznik

2014

Tom

Vol. 10, no. 3

Strony

101--115

Opis fizyczny

Bibliogr. 101 poz., rys., wykr.

Twórcy

autor

Piwowar M.

Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Kraków, Poland

autor

Dygut J.

Hospital in Przemyśl, Przemyśl, Poland

autor

Piwowar P.

AGH University of Science and Technology, Pawilon B-1, Kraków, Poland

autor

Konieczny L.

Chair of Medical Biochemistry, Jagiellonian University – Medical College, Kraków, Poland

autor

Roterman I.

myroterm@cyf-kr.edu.pl

Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Łazarza 16, 31-530 Kraków, Poland

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