Preliminary study on the electrospun PLA–based nanofibres as biomaterials for the treatment of cartilage

• Autorzy: Magiera A. , Markowski J. , Lesiuk M. , Sieroń A. L , Pilch J. , Błażewicz S.
• Konferencja: 24th Conference on Biomaterials in medicine and veterinary medicine : 9--12 October 2014, Rytro, Poland
• Języki publikacji: EN

Abstrakty

EN

Electrospinning is a simple and universal way to produce fibres from a variety of materials having diameters ranging from submicrometers to nanometers. Such fibres can be formed from resorbable and non-resorbable polymers, ceramics and their different combinations containing nanoparticles. Such a method has gained a great interest in medicine due to its ability to form a fibrous space architecture, similar to the natural extracellular matrix [1,2]. On the other hand, due to a wide range of technical facilities of electrospun fibers the method allows to create directionally-dependent space architecture of nanofibres which mimic natural tissues [3]. Considering the similarities between the microstructure created by nanofibres and the extracellular matrix, nanofibrous materials made by ES technique seem to be promising scaffolds to regenerate cartilage [4] and neural tissue [5]. A material which is used for cartilage scaffolds should mimic native cartilage, which is known to have an oriented structure associated with its mechanical and physiological functions [5]. Scaffold with a biomimetic-oriented architecture is an important requirement for tissue-engineered cartilage. In this study, PLA oriented and non-oriented fibrous scaffolds were manufactured. Selected properties of the materials were analysed and dissussed in view of the manufacture of optimal structure for cartilage tissue engineering.

Słowa kluczowe

EN

electrospinning; nanofibrous scaffold; cartilage

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2014
• Tom: Vol. 17, no. 128-129
• Strony: 110--111
• Opis fizyczny: Bibliogr. 5 poz., zdj.

Twórcy

autor

Magiera A.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland

autor

Markowski J.

• Medical University of Silesia, Department of Laryngology, ul. Francuska 20, 40-752 Katowice, Poland

autor

Lesiuk M.

• Medical University of Silesia, Department of General, Molecular Biology and Genetics, ul. Medyków 18, 40-752 Katowice, Poland

autor

Sieroń A. L

• Medical University of Silesia, Department of General, Molecular Biology and Genetics, ul. Medyków 18, 40-752 Katowice, Poland

autor

Pilch J.

• Medical University of Silesia, Department of Laryngology, ul. Francuska 20, 40-752 Katowice, Poland

autor

Błażewicz S.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland

Bibliografia

• [1] Spaddacio C., Rainer A., Trombetta M., Vadala G., Chello M., Covino E., Denaro V., Toyoda Y., Genovese J.A.: Poly-L-lactic acid/hydroxyapatite electrospun nanocomposites induce chondrogenic differentiation of human MSC. Annals of Biomedical Engineering 37 (2009) 1376-89
• [2] Xin X., Hussain M., Mao J.: Continuing differentiation of human mesenchymal stem cells and induced chondrogenic and osteogenic lineages in electrospun PLGA nanofiber scaffold. Biomaterials 28 (2007) 316-25
• [3] Jia S., Liu L., Pan W., Meng G., Duan C., Zhang L.: Oriented cartilage extracellular matrix-derived scaffold for cartilage tissue engineering. Journal of Bioscience and Bioengineering 113 (2012) 647-653
• [4] Lia W.J., Tulia R., Okafora C., Derfoula A., Danielsonb K.G., Halla D.J., Tuan R.S.: A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials 26 (2005) 599-609
• [5] Yang F., Qu X., Cui W., Bei J., Yu F., Lu S., Wang S.: Manufacturing and morphology structure of polylactide-type microtubules orientation-structured scaffolds. Biomaterials 27 (2006) 4923-4933

Uwagi

EN

This work was supported by the National Science Centre, PRELUDIUM 6 research program and project no. 2013/11/N/ST8/01169.