Laser-modified PLGA for implants: in vitro degradation and mechanical properties

• Autorzy: Kobielarz Magdalena , Tomanik Magdalena , Mroczkowska Katarzyna , Szustakiewicz Konrad , Oryszczak Magdalena , Mazur Anna , Antończak Arkadiusz , Filipiak Jarosław

Identyfikatory

DOI

10.37190/ABB-01532-2019-02

• Języki publikacji: EN

Abstrakty

EN

Irradiations of poly(lactic-co-glycolic acid) surface by CO2 laser lead to alterations of physicochemical properties of the copolymer. Effects of PLGA irradiations depend on the process parameters determining different cases of surface modification. Hence the main goal of presented studies was to define the influence of CO2 laser irradiation with different process parameters, inducing three cases of surface modification, on mechanical properties and topography of PLGA during degradation in the aqueous environment. Methods: Hydrolytic degradation of untreated and treated by CO2 laser thin specimens of PLGA was performed in distilled (demineralized) water. Mechanical properties of PLGA specimens before and during incubation were conducted in accordance with the PN-EN ISO 527-3:1998 standard. The pH of incubation solutions, topographies, masses and geometrical dimensions of specimens were controlled during the process. Results: During the hydrolytic degradation, gradual changes in failure mode were observed from ductile failure characteristic for untreated PLGA to brittle failure of incubated PLGA regardless of the case of induced modification. Tensile strength decreased with degradation time regardless of the case of surface modification with insignificant fluctuation Young’s moduli at the level of means. The pH of solutions for each case decreased and topography od specimens become smoother with incubation time. Conclusions: PLGA surface modification by CO2 laser below the ablation threshold (P1) and at the ablation threshold (P2) led to surface functionalization, however, irradiation above the ablation threshold (P3) caused marked degradation of PLGA and accelerated specimens disintegration during incubation in the aquatic environment.

Słowa kluczowe

EN

biodegradable polymer; poly(lactic-co-glycolic acid); implant; laser surface modification; mechanical properties

PL

biodegradowalny polimer; poly(lactic-co-glycolic acid); implant; laserowa modyfikacja powierzchni; właściwości mechaniczne

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2020
• Tom: Vol. 22, no. 1
• Strony: 179--192
• Opis fizyczny: Bibliogr. 30 poz., il., tab., wykr.

Twórcy

autor

Kobielarz Magdalena

• Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, ul. Łukasiewicza 7/9, 50-371 Wrocław

autor

Tomanik Magdalena

• Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wrocław, Poland

autor

Mroczkowska Katarzyna

• Laser and Fiber Electronics Group, Faculty of Electronics, Wrocław University of Science and Technology, Wrocław, Poland

autor

Szustakiewicz Konrad

• Department of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, Wrocław, Poland

autor

Oryszczak Magdalena

• Scientific Circle of Biomechanics, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wrocław, Poland

autor

Mazur Anna

• Scientific Circle of Biomechanics, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wrocław, Poland

autor

Antończak Arkadiusz

• Laser and Fiber Electronics Group, Faculty of Electronics, Wrocław University of Science and Technology, Wrocław, Poland

autor

Filipiak Jarosław

• Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wrocław, Poland

Bibliografia

• [1] AL-SUKHUN J., KONTIO R., LINDQVIST C., Bioresorbable poly-L/DL-lactide [P(L/DL)LA 70/30] plates are reliable for repairing of large inferior orbital wall bony defects: A pilot study, J. Oral. Maxil. Surg., 2006, 64, 47–55.
• [2] ANTOŃCZAK A.J., STȩPAK B.D., SZUSTAKIEWICZ K., WÓJCIK M.R., ABRAMSKI K.M., Degradation of poly(l-lactide) under CO2 laser treatment above the ablation threshold, Polym. Degrad. Stabil., 2014, 109, 97–105.
• [3] BARTKOWIAK-JOWSA M., BĘDZIŃSKI R., KOZŁOWSKA A., FILIPIAK J., PEZOWICZ C., Mechanical, rheological, fatigue, and degradation behavior of PLLA, PGLA and PDGLA as materials for vascular implants, Meccanica, 2013, 48, 721–731.
• [4] BHATLA A., YAO Y.L., Effect of laser surface modification on the crystallinity of poly(l-lactic acid), J. Manuf. Sci. Eng., 2009, 131, 51004-1-51004-11.
• [5] CARRASCO F., PAGÈS P., GÁMEZ-PÉREZ J., SANTANA O.O., MASPOCH M.L., Processing of poly(lactic acid): Characterization of chemical structure, thermal stability and mechanical properties, Polym. Degrad. Stabil., 2010, 95, 116–125.
• [6] ELMOWAFY E.M., TIBONI M., SOLIMAN M.E., Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles, J. Pharm. Investig., 2019, 49, 347–380.
• [7] FARAH S., ANDERSON D.G., LANGER R., Physical and mechanical properties of PLA, and their functions in widespread applications – A comprehensive review, Adv. Drug. Deliv. Rev., 2016, 107, 367–392.
• [8] FRANK D.S., MATZGER A.J., Effect of polymer hydrophobicity on the stability of amorphous solid dispersions and supersaturated solutions of a hydrophobic pharmaceutical, Mol. Pharm., 2019, 16, 682–688.
• [9] GUO M., CHU Z., YAO J., FENG W., WANG Y., WANG L., FAN Y., The effects of tensile stress on degradation of biodegradable PLGA membranes: A quantitative study, Polym. Degrad. Stabil., 2016, 124, 95–100.
• [10] HINES D.J., KAPLAN D.L., Poly(lactic-co-glycolic) acid-controlled-release systems: Experimental and modeling insights, Crit. Rev. Ther. Drug. Carrier Syst., 2013, 30, 257–276.
• [11] HOY R.S., Why is understanding glassy polymer mechanics so difficult?, J. Polym. Sci. Pol. Phys., 2011, 49, 979–984.
• [12] INTERNATIONAL, ORGANIZATION FOR STANDARDIZATION ISO 527-1:2012, Plastics – Determination of tensile properties – Part 1: General principles, Geneva 2012.
• [13] JIA W., LUO Y., YU J., LIU B., HU M., CHAI L., WANG C., Effects of high-repetition-rate femtosecond laser micromachining on the physical and chemical properties of polylactide (PLA), Opt. Express, 2015, 23, 26932–26939.
• [14] KOBIELARZ M., GAZIŃSKA M., TOMANIK M., STĘPAK B., SZUSTAKIEWICZ K., FILIPIAK J., ANTOŃCZAK A., PEZOWICZ C., Physicochemical and mechanical properties of CO2 laser- -modified biodegradable polymers for medical applications, Polym. Degrad. Stabil., 2019, 165, 182–195.
• [15] LAPUT O., VASENINA I., SALVADORI M.C., SAVKIN K., ZUZA D., KURZINA I., Low-temperature plasma treatment of polylactic acid and PLA/HA composite material, J. Mater. Sci., 2019, 54, 11726–11738.
• [16] LIEGER O., SCHALLER B., ZIX J., KELLNER F., IIZUKA T., Repair of orbital floor fractures using bioresorbable poly-L/DL-lactide plates, Arch. Facial. Plast. Surg., 2010, 12, 399–404.
• [17] MIDDLETON J.C., TIPTON A.J., Synthetic biodegradable polymers as orthopedic devices, Biomaterials, 2000, 21, 2335–2346.
• [18] MORACZEWSKI K., RYTLEWSKI P., MALINOWSKI R., ZENKIEWICZ M., Comparison of some effects of modification of a polylactide surface layer by chemical, plasma, and laser methods, Appl. Surf. Sci., 2015, 346, 11–17.
• [19] NIKOLSKAYA E., SOKOL, M., FAUSTOVA M., ZHUNINA O., MOLLAEV M., YABBAROV N., TERESHCHENKO O., POPOV R., SEVERIN E., The comparative study of influence of lactic and glycolic acids copolymers type on properties of daunorubicin loaded nanoparticles and drug release, Acta Bioeng. Biomech., 2018, 20 (1), 65–77.
• [20] OZDEMIR M., SADIKOGLU H., A new and emerging technology: Laser-induced surface modification of polymers, Trends Food Sci. Tech., 1998, 9, 159–167.
• [21] RENOUF-GLAUSER A.C., ROSE J., FARRAR D.F., CAMERON R.E., The effect of crystallinity on the deformation mechanism and bulk mechanical properties of PLLA, Biomaterials, 2005, 26, 5771–5782.
• [22] RYTLEWSKI P., MRÓZ W., ZENKIEWICZ M., CZWARTOS J., BUDNER B., Laser induced surface modification of polylactide, J. Mater. Process Tech., 2012, 212, 1700–1704.
• [23] SCHLIECKER G., SCHMIDT C., FUCHS S., WOMBACHER R., KISSEL T., Hydrolytic degradation of poly(lactide-co-glycolide) films: Effect of oligomers on degradation rate and crystallinity, Int. J. Pharm., 2003, 266, 39–49.
• [24] SIKORSKA W., MUSIOŁ M., RYDZ J., ZIĘBA M., RYCHTER P., LEWICKA K., ŠIŠKOVA A., MOSNÁČKOVÁ K., KOWALCZUK M., ADAMUS G., Prediction studies of environment-friendly biodegradable polymeric packaging based on PLA. Influence of specimens’ thickness on the hydrolytic degradation profile, Waste Manage, 2018, 78, 938–947.
• [25] STEPAK B., ANTOŃCZAK A.J., BARTKOWIAK-JOWSA M., FILIPIAK J., PEZOWICZ C., ABRAMSKI K.M., Fabrication of a polymer-based biodegradable stent using a CO2 laser, Arch. Civ. Mech. Eng., 2014, 14, 317–326.
• [26] ŚCIGAŁA K., BĘDZIŃSKI R., FILIPIAK J., CHLEBUS E., DYBAŁA B., Application of generative technologies in the design of reduced stiffness stems of hip joint endoprosthesis, Arch. Civ. Mech. Eng., 2011, 11, 753–767.
• [27] VERT M., Bioresorbable polymers for temporary therapeutic applications, Macromol. Mater. Eng., 1989, 166, 155–168.
• [28] WANG L., ZHANG Z., CHEN H., ZHANG S., XIONG C., Preparation and characterization of biodegradable thermoplastic elastomers (PLCA/PLGA blends), J. Polym. Res., 2010, 17, 77–82.
• [29] WANG S., CUI W., BEI J., Bulk and surface modifications of polylactide, Anal. Bioanal. Chem., 2005, 381, 547–556.
• [30] WAUGH D.G., LAWRENCE J., WALTON C.D., ZAKARIA R.B., On the effects of using CO2 and F2 lasers to modify the wettability of a polymeric biomaterial, Opt. Laser Technol., 2010, 42, 347–356.