Solution blow spun poly-L-lactic acid/ceramic fibrous composites for bone implant applications

• Autorzy: Wojasiński Michał , Ciach Tomasz

Identyfikatory

DOI

10.24425/cpe.2021.138931

• Języki publikacji: EN

Abstrakty

EN

Every bone implant to work correctly after implantation needs to integrate with the surrounding bone. To enhance such a process, called osseointegration, various techniques of implant surface modification emerged. One of the approaches is based on the deposition of nano- and submicron materials on the implant surface. This paper presents a solution blow spinning process for producing poly-L-lactic acid (PLLA)/ceramic fibrous composites designed to be deposited directly onto orthopaedic implants prior to implantation to increase osseointegration. We produced plain PLLA fibrous materials for comparison, and fibrous composite materials with 𝛽-tricalcium phosphate (𝛽TCP), hydroxyapatite nanoparticles (nHAp) and hydroxyapatite nanoparticles modified with lecithin (nHAp-LE). We performed the structural analysis of produced materials with scanning electron microscopy, gravimetric determination of porosity, and water contact angle measurement. We also used infrared spectroscopy, Alizarin Red S staining, and cytotoxicity evaluation to conclude that PLLA/nHAp-LE composite material shows the most promising properties to be applied as surface modification of bone implants. To visualise fibrous composite deposition on implants, we used two models: titanium plate and stainlesssteel bolt. Thus, we showed that the solution blow spun materials can be used for surface modification of orthopaedic implants.

Słowa kluczowe

EN

solution blow spinning; composite fibres; submicron fibres; nanofibres; poly-L-lactic acid; ceramic particles; bone implants

PL

wirowanie z rozdmuchiwaniem roztworu; włókna kompozytowe; włókna submikronowe; nanowłókna; kwas poli-L-mlekowy; cząstki ceramiczne; implanty kostne

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering
• Rocznik: 2021
• Tom: Vol. 42, nr 3
• Strony: 275--–289
• Opis fizyczny: Bibliogr. 32 poz., rys.

Twórcy

autor

Wojasiński Michał

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

autor

Ciach Tomasz

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland
• Warsaw University of Technology, Centre for Advanced Materials and Technologies CEZAMAT, Poleczki 19, 02-822 Warsaw, Poland

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