Needle-punched fibrous polycaprolactone scaffold for bone tissue engineering

• Autorzy: Rajzer I. , Grzybowska-Pietras J. , Fabia J. , Sarna E.
• Języki publikacji: EN

Abstrakty

EN

In the present work a three dimensional composite scaffolds for bone tissue engineering were created by a carding and needle-punch processes. Highly porous nonwoven fabrics were obtained from PCL and PCL/n-HAp cut fibers without the use of any chemicals during the manufacturing process. The properties of nonwoven scaffolds were examined by SEM, FTIR, DSC and TGA methods. The average pore diameter as well as the pore size distribution of nonwoven fabrics were measured by a capillary flow porometry. The obtained results suggest that needle-punching method can be used to produce highly porous microstructures with an interconnected pore network.

Słowa kluczowe

EN

needle-punched nonwovens; scaffold; hydroxyapatite; poly(ε-caprolactone)

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2013
• Tom: Vol. 16, no. 121
• Strony: 2--5
• Opis fizyczny: Bibliogr. 10 poz., rys., wykr.

Twórcy

autor

Rajzer I.

• ATH, University of Bielsko-Biala, 2 Wllowa Str., 43-309 Bielsko-Biała, Poland: Department of Mechanical Engineering Fundamentals, Division of Materials Engineering

autor

Grzybowska-Pietras J.

• ATH, University of Bielsko-Biala, 2 Wllowa Str., 43-309 Bielsko-Biała, Poland: Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Science

autor

Fabia J.

• ATH, University of Bielsko-Biala, 2 Willowa Str., 43-309 Bielsko-Biała, Poland: Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Science

autor

Sarna E.

• ATH, University of Bielsko-Biala, 2 Wllowa Str., 43-309 Bielsko-Biała, Poland: Faculty of Materials and Environmental Sciences, Institute of Textile Engineering and Polymer Science

Bibliografia

• [1] Chung S., Ingle N.P., Montero G.A., Kim S.H., King M.W.: Bioresorbable elastomeric vascular tissue engineering scaffolds via melt spinning and electrospinning. Acta Biomaterialia 6 (2010) 1958-1967.
• [2] Malheiro V.N., Caridade S.G., Alves N.M., Mano J.F.: New poly(ε-caprolactone)/Chitosan blend fibers for tissue engineering applications. Acta Biomaterialia 6 (2010) 418-428.
• [3] Rutkowska M., Krasowska K., Heimowska A., Steinka L., Janik H., Haponiuk J., Karlsson S.: Biodegradation of Modified Poly(ε-caprolactone) in Different Environments. Polish Journal of Environmental Studies Vol. 11, No. 4 (2002) 413-420.
• [4] Manjubala I., Woesz A., Pilz C., Rumpler M., Fratzl-Zelman N., Roscher P., Stampfl J., Fratzl P.: Biomimetic mineral-organic composite scaffolds with controlled internal architecture. Journal of Materials Science: Materials in Medicine 16 (2005) 1111-1119.
• [5] Zhang K., Yin A., Huang C., Wang C., Mo X., Al-Deyab S.S., El-Newehy M.: Degradation of electrospun SF/P(LLA-CL) blended nanofibrous scaffolds in vitro. Polymer Degradation and Stability 96 (2011) 2266-2275.
• [6] Santos M.I., Tuzlakoglu K., Fuchs S., Gomes M.E., Peters K., Unger R.E., Piskin E., Reis R.L., Kirkpatrick C.J.: Endothelial cell colonization and angiogenic potential of combined nano- and micro-fibrous scaffold for bone tissue engineering. Biomaterials 29 (2008) 4306-4313.
• [7] Rajzer I., Grzybowska-Pietras J., Janicki J.: Fabrication of bioactive carbon nonwovens for bone tissue regeneration. FIBRES & TEXTILES in Eastern Europe 19 (84) (2011) 66-72.
• [8] Shi Z., Huang X., Cai Y., Tangand R., Yang D.: Size effect of hydroxyapatite nanoparticles on proliferation and apoptosis of osteoblast-like cells. Acta Biomaterialia 5 (2009) 338-345.
• [9] Rajzer I., Fabia J., Graczyk T., Piekarczyk W.: Evaluation of PCL and PCL/n-HAp fibres processed by melt spinning. Engineering of Biomaterials 118 (2013) 2-4.
• [10] Ślósarczyk A., Paszkiewicz Z., Paluszkiewicz C.: FTIR and XRD evaluation of carbonated hydroxyapatite powders synthesized by wet methods. Journal of Molecular Structure 744-747 (2005) 657-661.

Uwagi

EN

This work was supported by the Minister of Science and Higher Education; project number N N507 550938.