Metody rozdzielania i oznaczania pozostałości β-blokerów i β-agonistów w próbkach środowiskowych

Caban, M.; Michalak, A.; Kumirska, J.

Artykuł - szczegóły

Tytuł artykułu

Metody rozdzielania i oznaczania pozostałości β-blokerów i β-agonistów w próbkach środowiskowych

Autorzy

Caban M. , Michalak A. , Kumirska J.

Treść / Zawartość

Pełne teksty:

Pobierz

Identyfikatory

Warianty tytułu

Methods of separation and determination of β-blockers and β-agonist residues in environmental samples

Języki publikacji

Abstrakty

Duża konsumpcja leków z grup β-blokerów i β-agonistów, niepełny metabolizm oraz niecałkowite usuwanie w oczyszczalniach ścieków sprawiają, że pozostałości tych farma-ceutyków są często wykrywane w próbkach środowiskowych, szczególnie w ekosystemach wodnych. Pomimo, iż stężenia tych związków nie są wysokie, stanowią one realne zagrożenie dla ekosystemu wodnego oraz zdrowia człowieka. Do oszacowania stopnia zanieczyszczenia środowiska tymi farmaceutykami oraz do oceny ryzyka ekotoksykologicznego wykorzystywane są metody chromatografii cieczowej i gazowej z detekcją masową. Obie te techniki wymagają wstępnej izolacji z próbek środowiskowych oraz wzbogacenia analitów powyżej granicy ozna-czalności użytej metody analitycznej. Najczęściej wykorzystuje się w tym celu ekstrakcję do fazy stałe. Trwają również prace na wykorzystaniem technik mikroekstrakcji. Poniższa praca przedstawia metody oznaczania β-blokerów i β-agonistów w próbkach środowiskowych.

High consumption of β-blockers and β-agonists drugs, exhaustive metabolism and incomplete removal in wastewater treatment plants make these pharmaceutical most frequently detected in environmental samples, especially in the water ecosystem. Although the concentra-tions of these compounds are not high, they represent a real risk to the aquatic ecosystem and human health. To estimate the degree of pollution and ecotoxicological risk assessment, gas and liquid chromatography with mass detection methods are used. Both of these techniques require the isolation and pre-concentrate of analytes from environmental matrices. Most commonly used is solid-phase extraction, although microextraction techniques are tested and adapted. The presented work provides a summary of methods for determining β-blockers and β-agonists in environmental samples.

Słowa kluczowe

β-blokery β-agoniści chromatografia gazowa chromatografia cieczowa spektrometria mas analiza pozostałości farmaceutyków w środowisku ekstrakcja do fazy stałej

β-blockers and β-agonists gas chromatography liquid chromatography mass spectrometry analysis of residues of pharmaceuticals solid-phase extraction

Wydawca

Publishing House of Siedlce University of Natural Sciences and Humanities

Czasopismo

Camera Separatoria

Rocznik

2012

Tom

Vol. 4, No. 1

Strony

61--79

Opis fizyczny

Bibliogr. 53 poz., tab.

Twórcy

autor

Caban M.

magdac@chem.univ.gda.pl

Uniwersytet Gdański, Wydział Chemii, Instytut Ochrony Środowiska i Zdrowia Człowieka, Zakład Analizy Środowiska, ul. Sobieskiego 18/19, 80-952 Gdańsk

autor

Michalak A.

Uniwersytet Gdański, Wydział Chemii, Instytut Ochrony Środowiska i Zdrowia Człowieka, Zakład Analizy Środowiska, ul. Sobieskiego 18/19, 80-952 Gdańsk

autor

Kumirska J.

Uniwersytet Gdański, Wydział Chemii, Instytut Ochrony Środowiska i Zdrowia Człowieka, Zakład Analizy Środowiska, ul. Sobieskiego 18/19, 80-952 Gdańsk

Bibliografia

1. B.I. Escher, N. Brama, M. Richter, J. Lineret, Comparative ecotoxicological hazard assessment of beta-blockers and their human metabolites using a mode-of-action-based test battery and QSAR approach, Environ. Sci. Technol., 40(2006)7402-7408.
2. L.H.M.L.M. Santos, A.N. Araújo, A. Fachini, A. Pena, C. Delerue-Matos, M.C.B.S.M. Montenegro, Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J. Hazard. Mater., 175(2010)45-95.
3. B.I. Escher, K. Fenner, Recent Advances in Environmental Risk Assessment of Transformation Products, Environ. Sci. Technol., 45(2011)3835–3847.
4. D. Fatta-Kassinos, S. Meric, A. Nikolaou, Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research., Anal. Bioanal. Chem., 399(2011)251–275.
5. C. Carlsson, A.K. Johansson, G. Alvan, K. Bergman, T. Kühler, Are pharmaceuticals potent environmental pollutants? Part II: Environmental risk assessments of selected pharmaceutical excipients., Sci. Total Environ., 364(2006)67-87.
6. H. Byrtus, G. Chłoń, M. Gorczyca, B. Łucka-Sobstel, B. Malawska, J. Obniska, M. Pawłowski, A. Zejc, “Chemia leków dla studentów farmacji i farmaceutów”, Chemistry of drugs for pharmacy students and pharmacists, Wydawnictwo Lekarskie PZWL, Warszawa, 2002.
7. A. Danysz, R. Gryglewski, pod red., „Farmakologia podręcznik dla studentów medycyny”, Pharmacology handbook for medical students, Państwowy Zakład Wydawnictw Lekarskich, Warszawa, 1977.
8. W. Kostowski, S.Z. Herman, pod red., „Farmakologia: podstawy farmakologii podręcznik dla studentów medycyny i lekarzy”, Pharmacology: Basic pharmacology handbook for students of medicine and doctor, Wydawnictwo Lekarskie PZWL, Warszawa, 2008.
9. www.antydoping.pl/plik/2009/File/2009/01/lista_zabroniona_wada_2010_pl.pdf
10. W. Buczko, T.F. Krzemiński, S.J. Czuczwar, „Farmakologia Goodmana & Gilmana”, Farmacology of Goldman & Gilman, tom I, Czelej, Lublin, 2007.
11. J.K. Podlewski, A. Chwalibogowska-Podlewska, „Leki współczesnej terapii, Encyklopedia dla lekarzy i farmaceutów”, Drugs of contemporary treatment, Encyclopedia for doctors and pharmacists, wydanie XX, tom I i II, Medical Tribune Polska, Warszawa, 2010.
12. C. Jiménez, R. Ventura, X. de la Torre, J. Segura, Strategies for internal quality control in antidoping analyses, Anal. Chim. Acta, 460(2002)389-307.
13. C. Miège, M. Favier, C. Brosse, J. Canler, M. Coquery, Occurence of betablockers In effluents of wastewater treatment plants from the Lyone area (France) and risk assessment for the downstream rivers, Talanta, 70(2006)739-744.
14. N.M. Vieno, T. Tuhkanen, L. Kronberg, Analysis of neutral and basic pharmaceuticals in sewage treatment plants and in recipient rivers using solid phase extraction and liquid chromatography–tandem mass spectrometry detection, J. Chromatogr. A, 1134(2006)101–111.
15. D.B. Huggett, I.A. Khan, C.M. Foran, D. Schlenk, Determination of beta-adrenergic receptor blocking pharmaceutical in United States wastewater effluent, Environ. Poll., 121(2003)199–205.
16. F. Sacher, F.T. Lange, H. Brauch, I. Blankenhorn, Pharmaceuticals in groundwaters: Analytical methods and results of a monitoring program in Baden-Württemberg, Germany, J. Chromatogr. A, 938(2001)199–210.
17. B. Kasprzyk-Hordern, R.M. Dinsdale, A.J. Guwy, Multi-residue method for the determination of basic/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography–positive electrospray ionisation tandem mass spectrometry, J. Chromatogr. A, 1161(2007)132–145.
18. A.C. Alder, C. Schaffner, M. Majewsky, J. Klasmeier, K. Fenner, Fate of β-blocker human pharmaceuticals in surface water: Comparison of measured and simulated concentrations in the Glatt Valley Watershed, Switzerland, Water Res., 44(2010)936-948.
19. R. Andreozzi, M. Raffaele, P. Nicklas, Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment, Chemosphere, 50(2003)1319–1330.
20. Q.T. Liu, H. Williams, Kinetics and degradation products for direct photolysis of β-blockers in water, Environ. Sci. Technol., 41(2007)803-810.
21. R.A. Trenholm, B.J. Vanderford, S.A. Snyder, On-line solid phase extraction LC-MS/MS analysis of pharmaceuticals indicator in water: A green alternative to conventional methods, Talanta, 79(2009)1425-1432.
22. S. Weigel, R. Kallenborn, H. Hühnerfuss, Simultaneous solid-phase extraction of acidic, neutral and basic pharmaceuticals from aqueous samples at ambient (neutral) pH and their determination by gas chromatography-mass spectrometry, J. Chromatogr. A, 1023(2004)183-195.
23. E. Pujos, C. Cren-Olivé, O. Paisse, M.M. Flament-Waton, M.F. Grenier-Loustalot, Comparison of the analysis of β-blockers by different techniques, J. Chromatogr. B, 877(2009)4007–4014.
24. R. Andreozzi, M. Raffaele, P. Nicklas, Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment, Chemosphere, 50(2003)1319–1330.
25. T.A. Ternes, Analytical methods for the determination of pharmaceuticals in aqueous environmental samples, Trends Anal. Chem., 8(2001)419-434.
26. H. Lee, K. Sarafin, T.E. Peart, Determination of β-blockers and β2-agonists in sewage by solid-phase extraction and liquid chromatography–tandem mass spectrometry, J. Chromatogr. A, 1148(2007)158–167.
27. M.D. Hernando, M. Petrovic, A.R. Fernández-Alba, D. Barceló, Analysis by liquid chromatography–electrospray ionization tandem mass spectrometry and acute toxicity evaluation for β-blockers and lipid-regulating agents in wastewater samples, J. Chromatogr. A, 1046(2004)133–140.
28. M. Scheurer, M. Ramil, C.D. Metcalfe, S. Groh, T.A. Ternes, The challenge of analyzing beta-blocker drugs in sludge and wastewater, Anal. Bioanal. Chem., 396(2009)845-856.
29. A. Piram, A. Salvador, J. Gauvrit, P. Lanteri, R. Faure, Development and optimisation of a single extraction procedure for the LC/MS/MS analysis of two pharmaceutical classes residues in sewage treatment plant, Talanta, 74(2008)1463–1475.
30. T.A. Ternes, R. Hirsch, J. Mueller, K. Haberer, Methods for the determination of neutral drugs as well as betablockers and β2-sympathomimetics in aqueous matrices using GC/MS and LC/MS/MS, J. Anal. Chem., 362(1998)329-340.
31. S.L. MacLeod, P. Sudhir, C.S. Wong, Stereoisomer analysis of wastewater-derived β-blockers, selective serotonin re-uptake inhibitors, and salbutamol by high-performance liquid chromatography–tandem mass spectrometry, J. Chromatogr. A, 1170(2007)23–33.
32. J. Namieśnik, Z. Jamrógiewicz, M. Pilarczyk, L. Torres, „Przygotowanie próbek środowiskowych do analizy”, Preparation of environmental samples for analysis, Wydawnictwo Naukowo-Techniczne, Warszawa, 2000.
33. M.K. Angier, R.J. Lewis, A.K. Chaturvedi, D.V. Canfield, Gas Chromatographic/Mass Spectrometric Differentiation of Atenolol, Metoprolol, Propranolol, and an Interfering Metabolite Product of Metoprolol, J. Anal. Toxicol., 29(2005)517–521.
34. M. Kostopoulou, A. Nikolaou, Analytical problems and the need for sample preparation in the determination of pharmaceuticals and their metabolites in aqueous environmental matrices, Trends Anal. Chem., 27(2008)1023-1035.
35. D. Fatta, A. Nikolaou, A. Achilleos, S. Meriç, Analytical methods for tracing pharmaceutical residues in water and wastewater, Trends Anal. Chem., 26(2007)515-533.
36. D.B. Huggett, I.A. Khan, C.M. Foran, D. Schlenk, Determination of beta-adrenergic receptor blocking pharmaceutical in United States wastewater effluent, Environ. Poll., 121(2003)199–205.
37. J. Stevens-Garmon, J.E. Drewes, S.T. Khan, J.A. McDonald, E.R.V. Dickenson, Sorption of emerging trace organic compounds onto wastewater sludge solids, Water Res., 45(2011)3417-3426.
38. K.J. Bisceglia, J.T. Yu, M. Coelhan, E.J. Bouwer, A.L. Roberts, Trace determination of pharmaceuticals and other wastewater-derived micropollutants by solid phase extraction and gas chromatography/mass spectrometry, J. Chromatogr. A, 217(2010)558–564.
39. M. Gros, T.M. Pizzolato, M. Petrović, M.J.L. de Alda, D. Barceló, Trace level determination of β-blockers in waste waters by highly selective molecularly imprinted polymers extraction followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry, J. Chromatogr. A, 1189(2008)374-384.
40. S. Castiglioni, R. Bagnati, D. Calamari, R. Fanelli, E. Zuccato, A multiresidue analytical method using solid-phase extraction and high-pressure liquid chromatography tandem mass spectrometry to measure pharmaceuticals of different therapeutic classes in urban wastewaters, J. Chromatogr. A, 1092(2005)206-215.
41. R. Rodil, J.B. Quintana, P. López-Mahía, S. Muniategiu-Lorenzo, D. Prada-Rodríguez, Multi-residue analytical method for the determination of emerging pollutants in water by solid-phase extraction and liquid chromatography-tandem mass spectrometry, J. Chromatogr. A, 1216(2009)2958-2969.
42. J. Bones, K. Thomas, P.N. Nesterenko. B. Paull, Dual gradient LC method for the determination of pharmaceutical residues in environmental samples using a monolithic silica reversed phase column, Talanta, 70(2006)1117-1128.
43. R.S. Kadam, U.B. Kompella, Cassette analysis of eight beta-blockers in bovine eye sclera, choroid-RPE, retina and vitreous by liquid chromatography-tandem mass spectrometry, J. Chromatogr. B, 877(2009)253-260.
44. C. Basheer, J. Lee, S. Petersen-Bjergaard, K.E. Rasmussen, H.K. Lee, Simultaneous extraction of acidic and basic drugs at neutral sample pH: a novel electro-mediated microextraction approach, J. Chromatogr. A, 1217(2010)6661-6667.
45. M. Moeder, S. Schrader, M. Winkler, P. Popp, Solid-phase microextraction–gas chromatography–mass spectrometry of biologically active substances in water samples, J. Chromatogr. A, 873(2000)95-105.
46. X. Hu, J. Pan, Y. Hu, G. Li, Preparation and evaluation of propranolol molecularly imprinted solid-phase microextraction fiber for trace analysis of β-blockers in urine and plasma samples, J. Chromatogr. A, 1216(2009)190-197.
47. V. Ranta, E. Toropainen, A. Talvitie, S. Auriola, A. Urtti, Simultaneous determination of eight β-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro, J. Chromatogr. B, 772(2002)81-87.
48. B. Yilmaz, S. Arslan, V. Akba, Gas chromatography–mass spectrometry method for determination of metoprolol in the patients with hypertension, Talanta, 80(2009)346–351.
49. M.J. Paik, D.T. Nguyen, K.R. Kim, GC and MS Properties of β-Blockers as tert-Butyldimethylsilyl Derivatives and as Ethoxyxarbonyl/ Trimethylsilyl Derivatives, Chromatogr., 64(2006)673-679.
50. L. Damasceno, R. Ventura, J. Ortuño, J. Segura, Derivatization procedures for the detection of β2-agonists by gas chromatographic/mass spectrometric analysis, J. Mass Spectrom., 35(2000)1285–1294.
51. G. Forsdahl , T. Geisendorfer, G. Gnneiner, Identification of isopropyl substituted β-blocking agents in human urine by gas chromatography and tandem mass spectrometry, Chromatogr., 57(2003)519-524.
52. W. Liu, L. Zhang, Z. Wei, S. Chen, G. Chen, Analysis of β-agonists and β-blockers in urine using hollow fibre-protected liquid-phase microextraction with in situ derivatization followed by gas chromatogra-phy/mass spectrometry, J. Chromatogr. A,1216(2009)5340–5346.
53. M. Caban, P. Stepnowski, M. Kwiatkowski, N. Migowska, J. Kumirska, Determination of β-blockers and β-agonists using gas chromatography and gas chromatography-mass spectrometry- a comparative study of the derivatization step, J. Chromatogr. A, 1218(2011)8110-8122.

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-fd2c3064-cec9-44c5-8d94-850fdc1a8434