Metody rozdzielania i oznaczania pozostałości β-blokerów i β-agonistów w próbkach środowiskowych

Caban, M.; Michalak, A.; Kumirska, J.

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Metody rozdzielania i oznaczania pozostałości β-blokerów i β-agonistów w próbkach środowiskowych

Autorzy

Caban M. , Michalak A. , Kumirska J.

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Warianty tytułu

Methods of separation and determination of β-blockers and β-agonist residues in environmental samples

Języki publikacji

Abstrakty

Duża konsumpcja leków z grup β-blokerów i β-agonistów, niepełny metabolizm oraz niecałkowite usuwanie w oczyszczalniach ścieków sprawiają, że pozostałości tych farma-ceutyków są często wykrywane w próbkach środowiskowych, szczególnie w ekosystemach wodnych. Pomimo, iż stężenia tych związków nie są wysokie, stanowią one realne zagrożenie dla ekosystemu wodnego oraz zdrowia człowieka. Do oszacowania stopnia zanieczyszczenia środowiska tymi farmaceutykami oraz do oceny ryzyka ekotoksykologicznego wykorzystywane są metody chromatografii cieczowej i gazowej z detekcją masową. Obie te techniki wymagają wstępnej izolacji z próbek środowiskowych oraz wzbogacenia analitów powyżej granicy ozna-czalności użytej metody analitycznej. Najczęściej wykorzystuje się w tym celu ekstrakcję do fazy stałe. Trwają również prace na wykorzystaniem technik mikroekstrakcji. Poniższa praca przedstawia metody oznaczania β-blokerów i β-agonistów w próbkach środowiskowych.

High consumption of β-blockers and β-agonists drugs, exhaustive metabolism and incomplete removal in wastewater treatment plants make these pharmaceutical most frequently detected in environmental samples, especially in the water ecosystem. Although the concentra-tions of these compounds are not high, they represent a real risk to the aquatic ecosystem and human health. To estimate the degree of pollution and ecotoxicological risk assessment, gas and liquid chromatography with mass detection methods are used. Both of these techniques require the isolation and pre-concentrate of analytes from environmental matrices. Most commonly used is solid-phase extraction, although microextraction techniques are tested and adapted. The presented work provides a summary of methods for determining β-blockers and β-agonists in environmental samples.

Słowa kluczowe

β-blokery β-agoniści chromatografia gazowa chromatografia cieczowa spektrometria mas analiza pozostałości farmaceutyków w środowisku ekstrakcja do fazy stałej

β-blockers and β-agonists gas chromatography liquid chromatography mass spectrometry analysis of residues of pharmaceuticals solid-phase extraction

Wydawca

Publishing House of Siedlce University of Natural Sciences and Humanities

Czasopismo

Camera Separatoria

Rocznik

2012

Tom

Vol. 4, No. 1

Strony

61--79

Opis fizyczny

Bibliogr. 53 poz., tab.

Twórcy

autor

Caban M.

magdac@chem.univ.gda.pl

Uniwersytet Gdański, Wydział Chemii, Instytut Ochrony Środowiska i Zdrowia Człowieka, Zakład Analizy Środowiska, ul. Sobieskiego 18/19, 80-952 Gdańsk

autor

Michalak A.

Uniwersytet Gdański, Wydział Chemii, Instytut Ochrony Środowiska i Zdrowia Człowieka, Zakład Analizy Środowiska, ul. Sobieskiego 18/19, 80-952 Gdańsk

autor

Kumirska J.

Uniwersytet Gdański, Wydział Chemii, Instytut Ochrony Środowiska i Zdrowia Człowieka, Zakład Analizy Środowiska, ul. Sobieskiego 18/19, 80-952 Gdańsk

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