Synthesis and characterization of curcumin-encapsulated loaded on carboxymethyl cellulose with docking validation as α-amylase and α-glucosidase inhibitors

• Autorzy: Almehizia Abdulrahman A. , Al-Omar Mohamed A. , Al-Obaid Abdulrahman M. , Naglah Ahmed M. , Bhat Mashooq A. , Ghabbour Hazem A. , Khatab Tamer K. , Hassan Ashraf S.

Identyfikatory

DOI

10.2478/pjct-2024-0031

• Języki publikacji: EN

Abstrakty

EN

In reaction to the expanding predominance of diabetes mellitus, curcumin nanoparticles stacked on carboxymethyl cellulose (CMC) composite were effectively synthesized, characterized, and examined utilizing UV/Vis and FTIR spectroscopy combined with transmission electron microscopy (TEM). The bioactivity of curcumin (Cur), carboxymethyl cellulose (CMC), and curcumin nanoparticles stacked with carboxymethyl cellulose (CUR-CMC) was tried through atomic docking approval as an α-amylase and α-glucosidase inhibitor. The conclusion illustrated that the curcumin-supported CMC is more potent than CUR itself self the validation presented is compared with acarbose as a reference molecule and then CUR-CMC can presented as promising in curing hyperglycemia by decreasing the absorption of glucose.

Słowa kluczowe

EN

curcumin; carboxymethyl cellulose; α-Amylase; α-Glucosidase; diabetes mellitus treatment

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2024
• Tom: Vol. 26, nr 3
• Strony: 63--69
• Opis fizyczny: Bibliogr. 38 poz., rys., tab., wz.

Twórcy

autor

Almehizia Abdulrahman A.

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

autor

Al-Omar Mohamed A.

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

autor

Al-Obaid Abdulrahman M.

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

autor

Naglah Ahmed M.

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

autor

Bhat Mashooq A.

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

autor

Ghabbour Hazem A.

• School of health and biomedical sciences, RMIT University, Melbourne 3083, Australia
• Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt

autor

Khatab Tamer K.

• Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt

autor

Hassan Ashraf S.

• Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt

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