A 3D-CNT micro-electrode array for zebrafish ECG study including directionality measurement and drug test

• Autorzy: Shih Mulaine , Kuo Chia-Tung , Lin Min-Hsuan , Chuang Yung-Jen , Chen Hsin , Yew Tri-Rung

Identyfikatory

DOI

10.1016/j.bbe.2020.02.008

• Języki publikacji: EN

Abstrakty

EN

This study aims to demonstrate the applicability of three dimensional-carbon-nanotubes (3D-CNT) micro-electrode array for electrocardiogram (ECG) study on the premier vertebrate model zebrafish. The small-feature size and vectorial array of 3D-CNT micro-electrodes were designed to detect ECG signals with high spatial resolution. With 30 μm–85 μm spacing between electrodes, it enables to detect the directionality of the ECG signals, the change of the characteristic ECG wave-forms at different locations of an adult zebrafish heart. Besides, the preliminary drug response tests using 3D-CNT micro-electrode were also carried out, which validated the capability of real-time observation on drug-induced ECG signal changes. The 3D-CNT micro-electrode array is thus feasible for ECG research and cardiac drug screenings, and holds high potential for studying bioelectric signals of other living organ-isms in the future.

Słowa kluczowe

EN

3D-CNT electrode; microelectrode array; spatial resolution; zebrafish ECG; directionality measurement; drug screening

PL

elektroda 3D-CNT; rozdzielczość przestrzenna; elektrokardiografia; pomiar kierunkowości

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2020
• Tom: Vol. 40, no. 2
• Strony: 701--708
• Opis fizyczny: Bibliogr. 38 poz., rys., wykr.

Twórcy

autor

Shih Mulaine

• Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan

autor

Kuo Chia-Tung

• Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan

autor

Lin Min-Hsuan

• Department of Medical Science & Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan

autor

Chuang Yung-Jen

• Department of Medical Science & Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan

autor

Chen Hsin

• Institute of Electronics Engineering, National Tsing Hua University, Hsinchu, Taiwan

autor

Yew Tri-Rung

• Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan

Bibliografia

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).