Comprehensive chromatographic profiling of cannabis from 23 USA States marketed for medical purposes

• Autorzy: Al Bakain Ramia Z , Al-Degs Yahya , Cizdziel James V. , Elsohly Mahmoud A.

Identyfikatory

DOI

10.1556/1326.2020.00767

• Języki publikacji: EN

Abstrakty

EN

In this research, cannabis varieties represent 23 USA States were assayed by GC-FID to generate their complex chemical profiles informative for plants clustering. Results showed that 45 cannabinoids and terpenoids were quantified in all plant samples, where 8 cannabinoids and 18 terpenoids were identified. Among organics, Δ9-THC, CBN (cannabinoids) and Fenchol (terpenoid) not only showed the highest levels overall contents, but also were the most important compounds for cannabis clustering. Among States, Washington, Oregon, California and Hawaii have the highest cannabis content. GC-FID data were subjected to PCA and HCA to find (1) the variations among cannabis chemical profiles as a result of growing environment, (2) to reveal the compounds that were responsible for grouping cultivars between clusters and (3) finally, to facilitate the future profile prediction and States clustering of unknown cannabis based on the chemical profile. The 23 cannabis USA States were grouped into three clusters based on only Δ9-THC, CBN, C1 and Fenchol content. Cannabis classification based on GCprofile will meet the practical needs of cannabis applications in clinical research, industrial production, patients’ self-production, and contribute to the standardization of commercially-available cannabis cultivars in USA.

Słowa kluczowe

PL

cannabinoids; terpenoids; chemical profiles; GC-FID; USA states; PCA; HCA Clustering; Δ9-THC

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2021
• Tom: Vol. 33, no. 1
• Strony: 78--90
• Opis fizyczny: Bibliogr. 50 poz., rys., tab.

Twórcy

autor

Al Bakain Ramia Z

• Department of Chemistry, School of Science, The University of Jordan, 11942, Amman, Jordan

• https://orcid.org/0000-0003-0419-0828

autor

Al-Degs Yahya

• Chemistry Department, The Hashemite University, 150459, Zarqa, Jordan

autor

Cizdziel James V.

• Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA

autor

Elsohly Mahmoud A.

• National Center for Natural Products Research, University, MS 38677-1848, USA
• Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi University, MS 38677, USA

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).